Departement für Chemie, Biochemie und Pharmazie

Lehre & Forschung
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Lebenslauf

  • 1987-1992: Studies in Biology at the University of Bern (Switzerland). Diploma thesis on U7 snRNA expression in the lab of Daniel Schümperli, Institute of Zoology. 
  • 1992-1998: Ph.D. in the lab of Göran Akusjärvi at the Cell and Molecular Biology Department, Karolinska Institute, Stockholm (Sweden) and later at the Biomedical Center, Uppsala University (Sweden). Work on the regulation of alternative splicing in adenovirus.
  • 1998-1999: Postdoctoral work in the lab of Melissa Moore, HMMI/Brandeis University, Waltham, MA (U.S.A.). Research on the mechanism of nonsense-mediated RNA.
  • 2000-2009: Research group leader at the Institute of Cell Biology, University of Bern (Switzerland). Research on mRNA quality control. Research Fellow of the Cloëtta Foundation 2005-2009. Starting Grant of the European Research Council (ERC) awarded 2007.
  • Since 2010: Full professor of Biochemistry at the Department of Chemistry and Biochemistry / Department of Chemistry, Biochemistry and Pharmaceutical Sciences (since 2021), University of Bern.
  • Since 2014: Director of the NCCR RNA & Disease

 

Forschungsschwerpunkt

We are investigating post-transcriptional gene regulation in human cells with a particular emphasis on trying to decipher the molecular mechanism and the biological and medical implications of nonsense-mediated mRNA decay (NMD). NMD is an important mRNA quality control process that recognizes and degrades mRNPs that fail to properly terminate translation, but also regulates expression levels of many physiological mRNAs. 

Publikationen

Liste der im neuen BORIS Portal erfassten Publikationen

(Anpassung der Publikationen im BORIS Portal: https://boris-portal.unibe.ch)

Publication Year Type

Mitgliedschaften

  • RNA society
  • Swiss Society for Molecular and Cellular Biosciences (SSMCB), a part of Life Science Switzerland (LS2)