Prof. Dr. Oliver Mühlemann

Journal Article

Schubert, Katharina; Karousis, Evangelos D; Ban, Ivo; Lapointe, Christopher P; Leibundgut, Marc; Bäumlin, Emilie; Kummerant, Eric; Scaiola, Alain; Schönhut, Tanja; Ziegelmüller, Jana; Puglisi, Joseph D; Mühlemann, Oliver; Ban, Nenad (2023). Universal features of Nsp1-mediated translational shutdown by coronaviruses. Molecular cell, 83(19), 3546-3557.e8. Cell Press 10.1016/j.molcel.2023.09.002

Gurzeler, Lukas-Adrian; Link, Marion; Ibig, Yvonne; Schmidt, Isabel; Galuba, Olaf; Schoenbett, Julian; Gasser-Didierlaurant, Christelle; Parker, Christian N; Mao, Xiaohong; Bitsch, Francis; Schirle, Markus; Couttet, Philipp; Sigoillot, Frederic; Ziegelmüller, Jana; Uldry, Anne-Christine; Teodorowicz, Wojciech; Schmiedeberg, Niko; Mühlemann, Oliver; Reinhardt, Jürgen (2023). Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control. Cell reports, 42(9), p. 113056. Cell Press 10.1016/j.celrep.2023.113056

Nasif, Sofia; Colombo, Martino; Uldry, Anne-Christine; Schröder, Markus S; De Brot, Simone; Mühlemann, Oliver (2023). Inhibition of nonsense-mediated mRNA decay reduces the tumorigenicity of human fibrosarcoma cells. NAR cancer, 5(3), zcad048. Oxford University Press 10.1093/narcan/zcad048

Karousis, Evangelos D; Mühlemann, Oliver (2022). The broader sense of nonsense. Trends in biochemical sciences, 47(11), pp. 921-935. Elsevier Current Trends 10.1016/j.tibs.2022.06.003

Domanski, Michal; Dedic, Emil; Pérez, Maria Escura; Cléry, Antoine; Campagne, Sébastien; Uldry, Anne-Christine; Braga, Sophie; Heller, Manfred; Rabl, Julius; Afanasyev, Pavel; Boehringer, Daniel; Nováček, Jiří; Allain, Frédéric T; Mühlemann, Oliver (2022). 40S hnRNP particles are a novel class of nuclear biomolecular condensates. Nucleic acids research, 50(11), pp. 6300-6312. Oxford University Press 10.1093/nar/gkac457

De, Soumasree; Mühlemann, Oliver (2022). A comprehensive coverage insurance for cells: revealing links between ribosome collisions, stress responses and mRNA surveillance. RNA biology, 19(1), pp. 609-621. Taylor and Francis 10.1080/15476286.2022.2065116

Gurzeler, Lukas-Adrian; Ziegelmüller, Jana; Mühlemann, Oliver; Karousis, Evangelos D. (2022). Production of human translation-competent lysates using dual centrifugation. RNA biology, 19(1), pp. 78-88. Taylor and Francis 10.1080/15476286.2021.2014695

Eberle, Andrea B; Mühlemann, Oliver (2022). Tethered Function Assays to Elucidate the Role of RNA-Binding Proteins. Methods in molecular biology, 2537, pp. 285-306. Springer 10.1007/978-1-0716-2521-7_17

Park, Yeonkyoung; Park, Joori; Hwang, Hyun Jung; Kim, Leehyeon; Jeong, Kwon; Song, Hyun Kyu; Rufener, Simone C.; Mühlemann, Oliver; Kim, Yoon Ki (2021). Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction. Nucleic acids research, 49(14), pp. 8261-8276. Oxford University Press 10.1093/nar/gkab579

Karousis, Evangelos D.; Gypas, Foivos; Zavolan, Mihaela; Mühlemann, Oliver (2021). Nanopore sequencing reveals endogenous NMD-targeted isoforms in human cells. Genome biology, 22(1), p. 223. BioMed Central Ltd. 10.1186/s13059-021-02439-3

Reber, Stefan; Jutzi, Daniel; Lindsay, Helen; Devoy, Anny; Mechtersheimer, Jonas; Levone, Brunno Rocha; Domanski, Michal; Bentmann, Eva; Dormann, Dorothee; Mühlemann, Oliver; Barabino, Silvia M L; Ruepp, Marc-David (2021). The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separation. Nucleic acids research, 49(13), pp. 7713-7731. Oxford University Press 10.1093/nar/gkab582

Contu, Lara; Balistreri, Giuseppe; Domanski, Michal; Uldry, Anne-Christine; Mühlemann, Oliver (2021). Characterisation of the Semliki Forest Virus-host cell interactome reveals the viral capsid protein as an inhibitor of nonsense-mediated mRNA decay. PLoS pathogens, 17(5), e1009603. Public Library of Science 10.1371/journal.ppat.1009603

Levone, Brunno R.; Lenzken, Silvia C.; Antonaci, Marco; Maiser, Andreas; Rapp, Alexander; Conte, Francesca; Reber, Stefan; Mechtersheimer, Jonas; Ronchi, Antonella E.; Mühlemann, Oliver; Leonhardt, Heinrich; Cardoso, M. Cristina; Ruepp, Marc-David; Barabino, Silvia M.L. (2021). FUS-dependent liquid–liquid phase separation is important for DNA repair initiation. Journal of cell biology, 220(5) Rockefeller Institute Press 10.1083/jcb.202008030

Schubert, Katharina; Karousis, Evangelos D.; Jomaa, Ahmad; Scaiola, Alain; Echeverria, Blanca; Gurzeler, Lukas-Adrian; Leibundgut, Marc; Thiel, Volker; Mühlemann, Oliver; Ban, Nenad (2020). SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation. Nature structural & molecular biology, 27(10), pp. 959-966. Springer Nature 10.1038/s41594-020-0511-8

Annibaldis, Giuditta; Domanski, Michal; Dreos, René; Contu, Lara; Carl, Sarah; Kläy, Nina; Mühlemann, Oliver (2020). Readthrough of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay. Nucleic acids research, 48(18), pp. 10259-10279. Oxford University Press 10.1093/nar/gkaa758

Karousis, Evangelos D.; Gurzeler, Lukas Adrian; Annibaldis, Giuditta; Dreos, René; Mühlemann, Oliver (2020). Human NMD ensues independently of stable ribosome stalling. Nature communications, 11(1) Nature Publishing Group 10.1038/s41467-020-17974-z

Humphrey, Jack; Birsa, Nicol; Milioto, Carmelo; McLaughlin, Martha; Ule, Agnieszka M.; Robaldo, David; Eberle, Andrea B.; Kräuchi, Rahel; Bentham, Matthew; Brown, Anna-Leigh; Jarvis, Seth; Bodo, Cristian; Garone, Maria G.; Devoy, Anny; Soraru, Gianni; Rosa, Alessandro; Bozzoni, Irene; Fisher, Elizabeth M. C.; Mühlemann, Oliver; Schiavo, Giampietro; ... (2020). FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention. Nucleic acids research, 48(12), pp. 6889-6905. Oxford University Press 10.1093/nar/gkaa410

Loffreda, Alessia; Nizzardo, Monica; Arosio, Alessandro; Ruepp, Marc-David; Calogero, Raffaele A.; Volinia, Stefano; Galasso, Marco; Bendotti, Caterina; Ferrarese, Carlo; Lunetta, Christian; Rizzuti, Mafalda; Ronchi, Antonella; Mühlemann, Oliver; Tremolizzo, Lucio; Corti, Stefania; Barabino, Silvia M.L. (2020). miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis. Progress in neurobiology, 190, p. 101803. Elsevier 10.1016/j.pneurobio.2020.101803

Contu, Lara; Steiner, Silvio; Thiel, Volker; Mühlemann, Oliver (2019). The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence. CHIMIA, 73(6), pp. 374-379. Schweizerische Chemische Gesellschaft 10.2533/chimia.2019.374

Loughlin, Fionna E.; Lukavsky, Peter J.; Kazeeva, Tamara; Reber, Stefan; Hock, Eva-Maria; Colombo, Martino; Von Schroetter, Christine; Pauli, Phillip; Cléry, Antoine; Mühlemann, Oliver; Polymenidou, Magdalini; Ruepp, Marc-David; Allain, Frédéric H.-T. (2019). The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity. Molecular cell, 73(3), 490-504.e6. Cell Press 10.1016/j.molcel.2018.11.012

Karousis, Evangelos; Mühlemann, Oliver (2018). Nonsense-Mediated mRNA Decay Begins Where Translation Ends. Cold Spring Harbor Perspectives in Biology, 11(2), a032862. 10.1101/cshperspect.a032862

Nicholson, Pamela; Gkratsou, Asimina; Josi, Christoph; Colombo, Martino; Mühlemann, Oliver (2018). Dissecting the functions of SMG5, SMG7 and PNRC2 in nonsense-mediated mRNA decay of human cells. RNA - a publication of the RNA Society, 24(4), pp. 557-573. Cold Spring Harbor Laboratory Press 10.1261/rna.063719.117

Nasif, Sofia; Contu, Lara; Mühlemann, Oliver (2018). Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression. Seminars in cell & developmental biology, 75, pp. 78-87. Elsevier 10.1016/j.semcdb.2017.08.053

Mühlemann, Oliver; Karousis, Evangelos (2017). New functions in translation termination uncovered for NMD factor UPF3B. The EMBO journal EMBOpress 10.15252/embj.201798063

Balistreri, Giuseppe; Bognanni, Claudia; Mühlemann, Oliver (2017). Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay. Viruses, 9(1) MDPI 10.3390/v9010024

Colombo, Martino; Karousis, Evangelos D.; Bourquin, Joëll; Bruggmann, Rémy; Mühlemann, Oliver (2017). Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways. RNA - a publication of the RNA Society, 23(2), pp. 189-201. Cold Spring Harbor Laboratory Press 10.1261/rna.059055.116

Reber, Stefan; Stettler, Jolanda; Filosa, G.; Colombo, Martino; Jutzi, D.; Lenzken, S. C.; Schweingruber, Christoph; Bruggmann, Rémy; Bachi, A.; Barabino, S. M.; Mühlemann, Oliver; Ruepp, Marc-David (2016). Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants. EMBO journal, 35(14), pp. 1504-1521. Nature Publishing Group 10.15252/embj.201593791

Karousis, Evangelos; Nasif, Sofia; Mühlemann, Oliver (2016). Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact. Wiley Interdisciplinary Reviews: RNA, 7(5), pp. 661-682. Wiley 10.1002/wrna.1357

Mühlemann, Oliver (2016). Spermatogenesis Studies Reveal a Distinct Nonsense-Mediated mRNA Decay (NMD) Mechanism for mRNAs with Long 3′UTRs. PLoS genetics, 12(5), e1005979. Public Library of Science 10.1371/journal.pgen.1005979

Schweingruber, Christoph; Soffientini, Paolo; Ruepp, Marc-David; Bachi, Angela; Mühlemann, Oliver (2016). Identification of Interactions in the NMD Complex Using Proximity-Dependent Biotinylation (BioID). PLoS ONE, 11(3), e0150239. Public Library of Science 10.1371/journal.pone.0150239

Balistreri, Giuseppe; Horvath, Peter; Schweingruber, Christoph; Zünd, David; McInerney, Gerald; Merits, Andres; Mühlemann, Oliver; Azzalin, Claus; Helenius, Ari (2014). The Host Nonsense-Mediated mRNA Decay Pathway Restricts Mammalian RNA Virus Replication. Cell host & microbe, 16(3), pp. 403-411. Cell Press 10.1016/j.chom.2014.08.007

Joncourt, Raphael; Eberle, Andrea; Rufener, Simone; Mühlemann, Oliver; Song, Haiwei (2014). Eukaryotic Initiation Factor 4G Suppresses Nonsense-Mediated mRNA Decay by Two Genetically Separable Mechanisms. PLoS ONE, 9(8), e104391. Public Library of Science 10.1371/journal.pone.0104391

Zünd, David; Mühlemann, Oliver (2014). UPF1 RNA Immunoprecipitation from Mini-μ Construct–expressing Cells. Bio-protocol bio-protocol

Zünd, David; Mühlemann, Oliver (2014). Individual-nucleotide-resolution UV Cross-linking and Immunoprecipitation (iCLIP) of UPF1. Bio-protocol bio-protocoll

Jack, Thomas; Ruepp, Marc-David; Thompson, Andrew J.; Mühlemann, Oliver; Lochner, Martin (2014). Synthesis and Characterization of Photoaffinity Probes that Target the 5-HT<SUB>3</SUB> Receptor. CHIMIA, 68(4), pp. 239-242. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2014.239

Flury, Valentin; Restuccia, Umberto; Bachi, Angela; Mühlemann, Oliver (2014). Characterization of Phosphorylation- and RNA-Dependent UPF1 Interactors by Quantitative Proteomics. Journal of Proteome Research, 13(6), pp. 3038-3053. 10.1021/pr5002143

Nizzardo, Monica; Simone, Chiara; Salani, Sabrina; Ruepp, Marc-David; Rizzo, Federica; Ruggieri, Margherita; Zanetta, Chiara; Brajkovic, Simona; Moulton, Hong M.; Mühlemann, Oliver; Bresolin, Nereo; Comi, Giacomo P.; Corti, Stefania (2014). Effect of Combined Systemic and Local Morpholino Treatment on the Spinal Muscular Atrophy Δ7 Mouse Model Phenotype. Clinical therapeutics, 36(3), 340-356.e5. Elsevier 10.1016/j.clinthera.2014.02.004

Nicholson, Pamela; Josi, Christoph; Kurosawa, Hitomi; Yamashita, Akio; Mühlemann, Oliver (2014). A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD. Nucleic acids research, 42(14), pp. 9217-9235. Oxford University Press 10.1093/nar/gku645

Zünd, David; Mühlemann, Oliver (2013). Recent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation. Translation perspective, 1(2), pp. 1-6. Landes Bioscience 10.4161/trla.26977

Schweingruber, Christoph; Rufener, Simone C.; Zünd, David; Yamashita, Akio; Mühlemann, Oliver (2013). Nonsense-mediated mRNA decay — Mechanisms of substrate mRNA recognition and degradation in mammalian cells. Biochimica et biophysica acta - gene regulatory mechanisms, 1829(6-7), pp. 612-623. New York, N.Y.: Elsevier 10.1016/j.bbagrm.2013.02.005

Rufener, Simone C; Mühlemann, Oliver (2013). eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells. Nature structural & molecular biology, 20(6), pp. 710-717. New York, N.Y.: Nature Publishing Group 10.1038/nsmb.2576

Zünd, David; Gruber, Andreas; Zavolan, Mihaela; Mühlemann, Oliver (2013). Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3′ UTRs. Nature structural & molecular biology, 20(8), pp. 936-943. New York, N.Y.: Nature Publishing Group 10.1038/nsmb.2635

Metze, Stefanie; Herzog, Veronika A.; Ruepp, Marc-David; Mühlemann, Oliver (2013). Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways. RNA - a publication of the RNA Society, 19(10), pp. 1432-1448. Woodbury, N.Y.: Cold Spring Harbor Laboratory Press 10.1261/rna.038893.113

Stoecklin, Georg; Mühlemann, Oliver (2013). RNA decay mechanisms: Specificity through diversity. Biochimica et biophysica acta - gene regulatory mechanisms, 1829(6-7), pp. 487-490. New York, N.Y.: Elsevier 10.1016/j.bbagrm.2013.04.002

Vivarelli, Silvia; Lenzken, Silvia C.; Ruepp, Marc-David; Ranzini, Francesco; Maffioletti, Andrea; Alvarez, Reinaldo; Mühlemann, Oliver; Barabino, Silvia M. L.; Buratti, Emanuele (2013). Paraquat Modulates Alternative Pre-mRNA Splicing by Modifying the Intracellular Distribution of SRPK2. PLoS ONE, 8(4), e61980. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0061980

Mühlemann, Oliver (2012). Intimate liaison with SR proteins brings exon junction complexes to unexpected places. Nature structural & molecular biology, 19(12), pp. 1209-1211. New York, N.Y.: Nature Publishing Group 10.1038/nsmb.2454

Mühlemann, Oliver; Jensen, Torben Heick (2012). mRNP quality control goes regulatory. Trends in genetics, 28(2), pp. 70-77. Amsterdam: Elsevier Current Trends 10.1016/j.tig.2011.11.001

Yepiskoposyan, Hasmik; Aeschimann, Florian; Nilsson, Daniel; Okoniewski, Michal; Mühlemann, Oliver (2011). Autoregulation of the nonsense-mediated mRNA decay pathway in human cells. RNA - a publication of the RNA Society, 17(12), pp. 2108-2118. Woodbury, N.Y.: Cold Spring Harbor Laboratory Press 10.1261/rna.030247.111

de Turris, Valeria; Nicholson, Pamela; Zamudio Orozco, Rodolfo; Singer, Robert H.; Mühlemann, Oliver (2011). Cotranscriptional effect of a premature termination codon revealed by live-cell imaging. RNA - a publication of the RNA Society, 17(12), pp. 2094-2107. Woodbury, N.Y.: Cold Spring Harbor Laboratory Press 10.1261/rna.02918111

Aeby, Eric; Ullu, Elisabetta; Yepiskoposyan, Hasmik; Schimanski, Bernd; Roditi, Isabel; Mühlemann, Oliver; Schneider, André (2010). tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans. Nucleic acids research, 38(17), pp. 5833-5843. London: Oxford University Press 10.1093/nar/gkq345

Nicholson, Pamela; Mühlemann, Oliver (2010). Cutting the nonsense: the degradation of PTC containing mRNAs. Biochemical Society transactions, 38(6), pp. 1615-1620. London: Portland Press 10.1042/BST0381615

Mühlemann, Oliver; Lykke-Andersen, Jens (2010). How and where are nonsense mRNAs degraded in mammalian cells? RNA biology, 7(1), pp. 1-5. Georgetown, Tex.: Landes Bioscience

Nicholson, Pamela; Yepiskoposyan, Hasmik; Metze, Stefanie; Zamudio Orozco, Rodolfo; Kleinschmidt, Nicole; Mühlemann, Oliver (2010). Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cellular and molecular life sciences, 67(5), pp. 677-700. Basel: SP Birkhäuser Verlag Basel 10.1007/s00018-009-0177-1

Eberle, Andrea B.; Lykke-Andersen, Søren; Mühlemann, Oliver; Jensen, Torben Heick (2009). SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells. Nature structural & molecular biology, 16(1), pp. 49-55. New York, N.Y.: Nature Publishing Group 10.1038/nsmb.1530

Stalder, Lukas; Mühlemann, Oliver (2009). Processing bodies are not required for mammalian nonsense-mediated mRNA decay. RNA - a publication of the RNA Society, 15(7), pp. 1265-1273. Woodbury, N.Y.: Cold Spring Harbor Laboratory Press 10.1261/rna.1672509

Eberle, Andrea; Herrmann, Kai; Jäck, Hans-Martin; Mühlemann, Oliver (2009). Equal transcription rates of productively and nonproductively rearranged immunoglobulin mu heavy chain alleles in a pro-B cell line. RNA - a publication of the RNA Society, 15(6), pp. 1021-1028. Woodbury, N.Y.: Cold Spring Harbor Laboratory Press 10.1261/rna.1516409

Patil, Jaspal; Heiniger, Eva; Nussberger, Jürg; Schaffner, Thomas; Mühlemann, Oliver; Imboden, Hans (2009). Angiotensin II is an endogenous neurotransmitter for rat and human mesenteric resistance blood vessels. Journal of vascular research, 46(Suppl. 3), p. 34. Basel: Karger

Patil, Jaspal; Heiniger, Eva; Schaffner, Thomas; Mühlemann, Oliver; Imboden, Hans (2008). Angiotensinergic neurons in sympathetic coeliac ganglia innervating rat and human mesenteric resistance blood vessels. Regulatory peptides, 147(1-3), pp. 82-87. Amsterdam: Elsevier 10.1016/j.regpep.2008.01.006

Eberle, Andrea B.; Stalder, Lukas; Mathys, Hansruedi; Zamudio Orozco, Rodolfo; Mühlemann, Oliver (2008). Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3' Untranslated Region. PLoS biology, 6(4), e92. Lawrence, Kans.: Public Library of Science 10.1371/journal.pbio.0060092

Mühlemann, Oliver (2008). Recognition of nonsense mRNA: towards a unified model. Biochemical Society transactions, 36(3), pp. 497-501. London: Portland Press 10.1042/BST0360497

Mühlemann, Oliver; Eberle, Andrea; Stalder, Lukas; Zamudio Orozco, Rodolfo (2008). Recognition and elimination of nonsense mRNA. Biochimica et biophysica acta - gene regulatory mechanisms, 1779(9), pp. 538-549. New York, N.Y.: Elsevier 10.1016/j.bbagrm.2008.06.012

Stalder, Lukas; Mühlemann, Oliver (2008). The meaning of nonsense. Trends in cell biology, 18(7), pp. 315-321. Cambridge: Elsevier Current Trends 10.1016/j.tcb.2008.04.005

Mühlemann, Oliver; Akusjarvi, Goran (2007). Preparation of soluble extracts from adenovirus-infected cells for studies of RNA splicing. Methods in molecular medicine, 131, pp. 33-46. Totowa, N.J.: Humana Press

Stalder, Lukas; Eberle, Andrea; Mühlemann, Oliver (2007). Quality control of gene expression: recognition of nonsense mRNAs prevents synthesis of truncated proteins. BioForum Europe(3), pp. 21-23. Darmstadt: GIT-Verlag

Stalder, Lukas; Mühlemann, Oliver (2007). Transcriptional silencing of nonsense codon-containing immunoglobulin micro genes requires translation of its mRNA. Journal of biological chemistry, 282(22), pp. 16079-16085. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M610595200

Buehler, Marc; Steiner, Silvia; Mohn, Fabio; Paillusson, Alexandra; Mühlemann, Oliver (2006). EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length (Brief Communications). Nature structural & molecular biology, 13(5), pp. 462-464. New York, N.Y.: Nature Publishing Group 10.1038/nsmb1081

Newbury, Sarah; Muehlemann, Oliver; Stoecklin, Georg (2006). Turnover in the Alps; an mRNA perspective. Review of EMBO Workshop on Mechanisms and Regulation of mRNA Turnover. EMBO reports, 7(2), pp. 143-148. London: Nature Publishing Group 10.1038/sj.embor.7400628

Paillusson, Alexandra; Hirschi, Nadine; Vallan, Claudio; Azzalin, Claus M.; Mühlemann, Oliver (2005). A GFP-based reporter system to monitor nonsense-mediated mRNA decay. Nucleic acids research, 33(6), e54-e54. Oxford University Press 10.1093/nar/gni052

Bühler, Marc; Paillusson, Alexandra; Mühlemann, Oliver (2004). Efficient downregulation of immunoglobulin μ mRNA with premature translation-termination codons requires the 5′-half of the VDJ exon. Nucleic acids research, 32(11), pp. 3304-3315. Oxford University Press 10.1093/nar/gkh651

Book Section

Nicholson, Pamela; Joncourt, Raphael; Mühlemann, Oliver (2012). Analysis of Nonsense-Mediated mRNA Decay in Mammalian Cells. In: Current Protocols in Cell Biology 55 (27.4.1.-27.4.61). Chichester: John Wiley & Sons 10.1002/0471143030.cb2704s55

Eberle, Andrea; Lykke-Andersen, Søren; Stalder, Lukas; Jensen, Torben Heick; Mühlemann, Oliver (2009). SMG6-mediated endonucleolytic cleavage of nonsense mRNA in human cells. In: EMBO conference on "Protein synthesis and translational control", Heidelberg (Germany), September 9-13, 2009. European Molecular Biology Laboratory (EMBL)

Conference or Workshop Item

Karousis, Evangelos; Mühlemann, Oliver (27 January 2017). In vitro study of aberrant translation termination in the context of NMD-sensitive mRNAs (Unpublished). In: Swiss RNA Workshop 2017. Bern, Switzerland. 27.01.2017.

Mühlemann, Oliver (14 November 2016). Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways (Unpublished). In: Cold Spring Harbour Asia Conference “RNA Biology”. Suzhou, China. 14.-18.11.2016.

Gkratsou, Asimina; Nicholson, Pamela; Colombo, Martino; Mühlemann, Oliver (7 October 2016). Investigation of the role of PNRC2 in nonsense-mediated mRNA decay in human cells (Unpublished). In: EMBO | EMBL Symposium: The Complex Life of mRNA. EMBL Heidelberg, Germany. 05.-08.10.16.

Karousis, Evangelos; Mühlemann, Oliver (6 September 2016). In vitro study of aberrant translation termination in the context of a long 3΄UTR (Unpublished). In: Translational Control. Cold Spring Harbor Laboratory, New York, USA. 06.-10.09.16.

Mühlemann, Oliver (10 July 2016). What makes an NMD target? Identification and characterization of NMD sensitive endogenous transcripts in human cells (Unpublished). In: FASEB SRC on "Post-transcriptional control of gene expression: Mechanisms of RNA decay". Lisbon, Portugal. 10.-15.07.2016.

Gkratsou, Asimina; Mühlemann, Oliver (22 March 2016). Establishing a reporter assay to identify small molecule NMD inhibitors and new NMD factors (Unpublished). In: NCCR site visit 2016. Bern, Switzerland. 22.03.2016.

Gkratsou, Asimina; Mühlemann, Oliver (22 January 2016). Investigation of the interaction between UPF1 and the THO/TREX complex (Unpublished). In: Swiss RNA workshop 2016. Bern, Switzerland. 22.01.2016.

Karousis, Evangelos; Mühlemann, Oliver (22 January 2016). Molecular study of aberrant translation termination in mammalian systems (Unpublished). In: Swiss RNA Workshop 2016. Bern, Switzerland. 22.01.2016.

Nasif, Sofia; Mühlemann, Oliver (22 January 2016). Production of human cell lines with mutations and deletions in endogenous NMD factors using CRISPR/Cas genome editing (Unpublished). In: Swiss RNA Workshop 2016. Bern, Switzerland. 22.01.16.

Karousis, Evangelos; Mühlemann, Oliver (9 September 2015). Mechanistic study of premature termination codon recognition in mammalian systems (Unpublished). In: EMBO Conference Protein Synthesis and translational control. EMBL Heidelberg, Germany. 09.-13.09.2015.

Leuenberger, Michele; Jack, Thomas; Ruepp, Marc-David; Lagache, Sophie; Heller, Manfred; Mühlemann, Oliver; Thompson, Andrew J.; Lochner, Martin (15 June 2015). Synthesis of photo-crosslinking probes and their application for the site-selective chemical modification of the 5-HT3 receptor (Unpublished). In: Challenges in Chemical Biology (ISACS16). Book of Abstracts. ETH Zürich, Hönggerberg, Switzerland. 15.06.-18.06.2015.

Mühlemann, Oliver (6 July 2014). Nonsense-mediated mRNA decay (NMD) restricts replication of mammalian RNA viruses (Unpublished). In: Mechanisms of mRNA decay (FASEB SRC). Big Sky, Montana, USA. 06.07.-11.07.2014.

Mühlemann, Oliver (3 June 2014). SMG6 mediated degradation of nonsense mRNA requires phosphorylation-independent interaction with the helicase domain of UPF1 (Unpublished). In: 19th Annual Meeting of the RNA society. Quebec, Kanada. 03.06.-08.06.2014.

Mühlemann, Oliver (8 September 2013). Mechanistic aspects of NMD in human cells (Unpublished). In: EMBL Conference on Protein Synthesis and Translational Control. EMBL, Heidelberg, Germany. 08.-12.09.2013.

Jack, Thomas; Ruepp, Marc-David; Mühlemann, Oliver; Thompson, Andrew James; Lummis, Sarah C. R.; Lochner, Martin (August 2013). Synthesis and testing of photoaffinity probes for the site-selective chemical modification of the 5-HT3 receptor. CHIMIA, 67(7/8), p. 519. Schweizerische Chemische Gesellschaft

Singhanat, Suradech; Ruepp, Marc-David; Jack, Thomas; Rougier, Jean-Sébastien; Abriel, Hugues; Mühlemann, Oliver; Lochner, Martin (August 2013). Towards the site-specific modification of the hERG K+ channel. CHIMIA, 67(7/8), p. 532. Schweizerische Chemische Gesellschaft

Mühlemann, Oliver (21 April 2013). Mechanistic aspects of mRNA targeting for nonsense-mediated mRNA decay in human cells (Unpublished). In: EMBO Eucaryotic RNA turnover conference. IGBMC, Strasbourg, France. 21.-24.04.2013.

Flury, Valentin; Restuccia, Umberto; Bachi, Angela; Mühlemann, Oliver (2012). Quantitative interactomics of UPF1, a key player in NMD. In: Swiss RNA Workshop 2012 Posters.

Metze, Stefanie; Mühlemann, Oliver (2012). mRNA Degradation in Exon Junction Complex-Independent NMD. In: Graduate School for Cellular and Biomedical Sciences GCB Students' Symposium 2012 Posters.

Metze, Stefanie; Mühlemann, Oliver (2012). mRNA Degradation in Exon Junction Complex-Independent NMD. In: Swiss RNA Workshop 2012 Posters.

Jack, Thomas; Ruepp, Marc-David; Mühlemann, Oliver; Thompson, Andrew J.; Lummis, Sarah C.R.; Lochner, Martin (2012). Synthesis of photoaffinity probes for the site-selective chemical modifications of the 5-HT3 receptor. In: Swiss Chemical Society Fall Meeting 2012 Posters.

Jack, Thomas; Ruepp, Marc-David; Mühlemann, Oliver; Thompson, Andrew J.; Lummis, Sarah C.R.; Lochner, Martin (2012). Synthesis of photoaffinity probes for the site-selective chemical modifications of the 5-HT3 receptor. In: CUSO Summer School 2012 Posters.

Ruepp, Marc-David; Mühlemann, Oliver (2012). Unrevelling the multiple roles of FUS in RNA processing and the impact of microRNAs on ALS pathogenesis. In: Swiss RNA Workshop 2012 Posters.

Rufener, Simone C.; Mühlemann, Oliver (2012). Is mammalian NMD restricted to pioneer rounds of translation? In: Swiss RNA Workshop 2012 Posters.

de Turris, Valeria; Nicholson, Pamela; Orozco, Rodolfo Zamudio; Mühlemann, Oliver; Singer, Robert H. (2012). Retention of Nonsense mRNA at the Site of Transcription. In: Swiss RNA Workshop 2012 Abstracts.

Nicholson, Pamela; Yamashita, Akio; Mühlemann, Oliver (2012). Unrevelling the mechanism of RNA degradation in the nonsense-mediated mRNA decay pathway. In: Swiss RNA Workshop 2012 Posters.

Metze, Stefanie; Herzog, Veronika; Mühlemann, Oliver (2012). Commonalities and differences between the EJC-enhanced and EJC-independent mode of NMD in human cells. In: FASEB-SRC on Post-transcriptional control of gene expression: mechanisms of mRNA decay, Steamboat Springs, CO, USA.

Nicholson, Pamela; Mühlemann, Oliver (2012). Dissecting the mammalian nonsense-mediated mRNA decay pathway by a combined tethering / knockdown approach. In: 17th Annual Meeting of the RNA Society, Ann Arbor MI, USA.

Nicholson, Pamela; Mühlemann, Oliver (2012). Unrevelling the mammalian nonsense-mediated mRNA decay pathway by a combined tethering / knockdown approach. In: EMBO/EMBL Symposium 7.10.2012-10.10.2012 - The Complex Life of mRNA, Heidelberg (D) Posters.

Joncourt, Raphael; Eberle, Andrea; Mühlemann, Oliver (2011). mRNP components involved in PTC-recognition. In: Swiss RNA Workshop January 2011 (p. 1). Bern: Universität Bern

Joncourt, Raphael; Eberle, Andrea; Mühlemann, Oliver (2011). Investigation of premature termination codon recognition in nonsense mediated mRNA decay. In: EMBO Conference Series on Protein Synthesis and Translational Control, Heidelberg 7-11 September 2011 (p. 1). European Molecular Biology Laboratory (EMBL)

Metze, Stefanie; Mühlemann, Oliver (2011). Investigation of aberrant vs. normal translation termination in HeLa extracts. In: The 16th Annual Meeting of the RNA Society Kyoto, Japan, June 14-18, 2011. RNA Society

Metze, Stefanie; Mühlemann, Oliver (2011). Analysis of (premature) stop codon recognition in HeLa translation extracts. In: Grad School Symposium, Bern, January 28, 2011. Bern: Universität Bern

Metze, Stefanie; Herzog, Veronika; Mühlemann, Oliver (2011). Alternative pathways of nonsense-mediated mRNA decay. In: Swiss RNA Workshop January 2011. Bern: Universität Bern

Metze, Stefanie; Mühlemann, Oliver (2011). Investigation of aberrant vs. normal translation termination in HeLa extracts. In: 62. Mosbacher Kolloquium 2011: Mechanisms of RNA-mediated regulation, Mosbach, Deutschland, April 7-9, 2011 (p. 1). Gesellschaft für Biochemie und Molekularbiologie GBM

Nicholson, Pamela; Mühlemann, Oliver (2011). Understanding the mechanism of mRNA degradation in the nonsense-mediated decay pathway. In: Swiss RNA Workshop January 2011. Bern: Universität Bern

Nicholson, Pamela; Mühlemann, Oliver (2011). Understanding the mechanism of RNA degradation in the mammalian nonsense-mediated mRNA decay pathway. In: Swiss RNA Workshop January 2011. RNA Society

Schweingruber, Christoph; Mühlemann, Oliver (2011). Assessing differential susceptibility of mRNAs to NMD. In: EMBO Practical Course on Analysis of High-Throughput Sequencing Data: Poster Session, October 2011. European Molecular Biology Laboratory (EMBL)

Vivarelli, S.; Lenzken, S.C.; Ruepp, M.-D.; Maffioletti, A.; Ranzini, F.; Mühlemann, Oliver; Barabino, S.M.L. (2011). Genotoxic stress affects alternative pre-mRNA splicing: involvement of SRPK2. In: The 16th Annual Meeting of the RNA Society Kyoto, Japan, June 14-18, 2011. RNA Society

Nicholson, Pamela; Mühlemann, Oliver (2010). Understanding the mechanism of RNA degradation in the nonsense-mediated mRNA decay pathway. In: Conference - Post transcriptional control: mRNA translation, localization and turnover, 8th-10th June, Edinburgh, Scotland.

Nicholson, Pamela; Stalder, Lukas; Eberle, Andrea; Bühler, Marc; Mühlemann, Oliver (2010). Investigating nonsense-mediated transcriptional gene silencing: a novel quality-control mechanism. In: Abstract Swiss RNA workshop January 2010 (p. 1). Bern: Universität Bern

Zünd, David; Joncourt, Raphael; Mühlemann, Oliver (2010). Two different degradation pathways in nonsense-mediated mRNA decay? In: Abstract Swiss RNA workshop January 2010 (p. 1). Bern: Universität Bern

Yepiskoposyan, Hasmik; Aeschimann, Florian; Mühlemann, Oliver (2010). Microarray analysis of NMD depletion in human cells. In: Abstract Swiss RNA workshop January 2010 (p. 1). Bern: Universität Bern

Yepiskoposyan, Hasmik; Aeschimann, Florian; Mühlemann, Oliver (2010). Most mRNAs encoding human NMD factors are NMD substrates: evidence for auto-regulation. In: ESF RNAquality Conference, Vienna, May 10-13, 2010.

Yepiskoposyan, Hasmik; Aeschimann, Florian; Mühlemann, Oliver (2010). Most mRNAs encoding human NMD factors are NMD substrates: evidence for auto-regulation. In: The Fifteenth Annual Meeting of the RNA Society Seattle, Washington USA, June 22-26, 2010 (p. 1). RNA Society

Mühlemann, Oliver; Yepiskoposyan, Hasmik; Aeschimann, Florian (2010). Most mRNAs encoding human NMD factors are NMD substrates: evidence for auto-regulation. In: Post-transcriptional control of gene expression, FASEB summer research conference, Carefree Arizona, USA.

De Turris, Valeria; Nicholson, Pamela; Zamudio, Rodolfo; Singer, Robert; Mühlemann, Oliver (2010). Live-cell imaging reveals that SMG6 and UPF1 inhibit release of nonsense mRNA from the transcription site. In: TERM 2010: RNA quality control meeting in Seillac, France.

Metze, Stefanie; Mühlemann, Oliver (2010). Analysis of (premature) stop codon recognition in HeLa translation extracts. In: The Complex Life of mRNA: From Synthesis to Decay, EMBO Conference Heidelberg on RNA processing.

Yepiskoposyan, Hasmik; Aeschimann, Florian; Mühlemann, Oliver (2010). Most mRNAs encoding human NMD factors are NMD substrates: evidence for auto-regulation. In: Gordon Research Conference on the Biology of Post-Transcriptional Gene Regulation. Newport, RI, USA.

Metze, Stefanie; Mühlemann, Oliver (2010). Analysis of (premature) stop codon recognition in HeLa translation extracts. In: Abstract Swiss RNA workshop January 2010 (p. 1). Bern: Universität Bern

Zünd, David; Flury, Valentin; Umberto, Restuccia; Heller, Manfred; Bachi, Angela; Mühlemann, Oliver (2010). UPF1: phosphoprotein, RNA helicase and NMD core factor. In: Swiss RNA Workshop January 2011. Bern: Universität Bern

Stalder, Lukas; Mühlemann, Oliver (2009). Processing bodies are not required for mammalian nonsense-mediated mRNA decay. In: Workshop "RNA Quality 2009", Gif sur Yvette, France, 13-15 May 2009. Strasbourg: European Science Foundation

Stalder, Lukas; Eberle, Andrea; Bühler, Marc; Nicholson, Pamela; Mühlemann, Oliver (2009). Nonsense-mediated transcriptional gene silencing: a puzzle far from being solved. In: Workshop "RNA Quality 2009", Gif sur Yvette, France, 13-15 May 2009. Strasbourg: European Science Foundation

Mühlemann, Oliver (2009). New insights into identification and degradation of nonsense mRNAs in human cells. In: 5th Meeting on RNA research in Carcavelos, Portugal, November 5-6, 2009.