Departement für Chemie, Biochemie und Pharmazie

Lehre & Forschung
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Lebenslauf

  • 1981-1985: Diploma studies in Chemistry and Biochemistry, ETH Zürich
  • 1986-1989: Ph.D. Thesis, Natural Products Synthesis, University of Lausanne
  • 1990-1991: Post-doc, Catalytic Antibodies, Scripps Research Institute
  • 1992-1997: Assistant Professor, Scripps Research Institute
  • 1997-present: Professor,  Department of Chemistry and Biochemistry / Department of Chemistry, Biochemistry and Pharmaceutical Sciences (since 2021), Universität Bern
  • 2015-2017: Director of the Department of Chemistry and Biochemistry, Universität Bern
  • 2024-present: Dean of the Faculty of Science, Universität Bern

Forschungsschwerpunkt

The Chemical Space Project

“Chemical space” describes the ensemble of all possible chemical compounds, in particular those of interest as drugs for medical use. Our work on chemical space unfolds in the following projects:

  • Peptide Chemistry: design, synthesis and evaluation of new bioactive topologically diverse peptides, in particular peptide dendrimers and polycyclic peptides as antimicrobials, biofilm inhibitors, cell penetrating and gene/si-RNA transfection reagents
  • Cheminformatics: enumeration of the chemical universe database GDB containing all possible organic molecules, new methods for the interactive visualization and virtual screening of chemical space (www.gdb.unibe.ch)
  • Medicinal Chemistry: computer-aided design and synthesis of small molecule modulators for transporter and ion channels, in part in the context of the NCCR TransCure (www.nccr-transcure.ch)

Publikationen

Liste der im neuen BORIS Portal erfassten Publikationen

(Anpassung der Publikationen im BORIS Portal: https://boris-portal.unibe.ch)

Publication Year Type