Departement für Chemie, Biochemie und Pharmazie

Lehre & Forschung
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Lebenslauf

  • 1981-1985: Diploma studies in Chemistry and Biochemistry, ETH Zürich
  • 1986-1989: Ph.D. Thesis, Natural Products Synthesis, University of Lausanne
  • 1990-1991: Post-doc, Catalytic Antibodies, Scripps Research Institute
  • 1992-1997: Assistant Professor, Scripps Research Institute
  • 1997-present: Professor,  Department of Chemistry and Biochemistry / Department of Chemistry, Biochemistry and Pharmaceutical Sciences (since 2021), Universität Bern
  • 2015-2017: Director of the Department of Chemistry and Biochemistry, Universität Bern
  • 2024-present: Dean of the Faculty of Science, Universität Bern

Forschungsschwerpunkt

The Chemical Space Project

“Chemical space” describes the ensemble of all possible chemical compounds, in particular those of interest as drugs for medical use. Our work on chemical space unfolds in the following projects:

  • Peptide Chemistry: design, synthesis and evaluation of new bioactive topologically diverse peptides, in particular peptide dendrimers and polycyclic peptides as antimicrobials, biofilm inhibitors, cell penetrating and gene/si-RNA transfection reagents
  • Cheminformatics: enumeration of the chemical universe database GDB containing all possible organic molecules, new methods for the interactive visualization and virtual screening of chemical space (www.gdb.unibe.ch)
  • Medicinal Chemistry: computer-aided design and synthesis of small molecule modulators for transporter and ion channels, in part in the context of the NCCR TransCure (www.nccr-transcure.ch)

Publikationen

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Journal Article

Jordan, Olivier; Gan, Bee-Ha; Alwan, Sari; Perron, Karl; Sublet, Emmanuelle; Ducret, Verena; Ye, Hua; Borchard, Gerrit; Reymond, Jean-Louis; Patrulea, Viorica (2024). Highly Potent Cationic Chitosan Derivatives Coupled to Antimicrobial Peptide Dendrimers to Combat Pseudomonas Aeruginosa. Advanced healthcare materials, 13(19), e2304118. Wiley 10.1002/adhm.202304118

Orsi, Markus; Reymond, Jean-Louis (2024). Can large language models predict antimicrobial peptide activity and toxicity? RSC Medicinal Chemistry, 15(6), pp. 2030-2036. Royal Society of Chemistry 10.1039/d4md00159a

Brühlmann, Francis; Perry, Carmen; Griessen, Charlotte; Gunasekera, Kapila; Reymond, Jean-Louis; Naguleswaran, Arunasalam; Rottenberg, Sven; Woods, Kerry; Olias, Philipp (2024). TurboID mapping reveals the exportome of secreted intrinsically disordered proteins in the transforming parasite Theileria annulata. mBio, 15(6), e0341223. American Society for Microbiology 10.1128/mbio.03412-23

Orsi, Markus; Reymond, Jean-Louis (2024). One chiral fingerprint to find them all. Journal of cheminformatics, 16(53) Springer 10.1186/s13321-024-00849-6

Amati, Andrea Marco; Moning, Stefan Urs; Javor, Sacha; Schär, Sandra; Deutschmann, Sabina; Reymond, Jean-Louis; von Ballmoos, Christoph (2024). Overcoming Protein Orientation Mismatch Enables Efficient Nanoscale Light-Driven ATP Production. ACS synthetic biology, 13(4), pp. 1355-1364. American Chemical Society 10.1021/acssynbio.4c00058

Bonvin, Etienne; Personne, Hippolyte; Paschoud, Thierry; Reusser, Jérémie; Gan, Bee-Ha; Luscher, Alexandre; Köhler, Thilo; van Delden, Christian; Reymond, Jean-Louis (2023). Antimicrobial Peptide-Peptoid Hybrids with and without Membrane Disruption. ACS infectious diseases, 9(12), pp. 2593-2606. American Chemical Society 10.1021/acsinfecdis.3c00421

Buehler, Ye; Reymond, Jean-Louis (2023). Expanding Bioactive Fragment Space with the Generated Database GDB-13s. Journal of chemical information and modeling, 63(20), pp. 6239-6248. American Chemical Society 10.1021/acs.jcim.3c01096

Meirelles, Matheus A.; Reymond, Jean-Louis (2023). Optimizing Phosphate Couplings for Dolichyl Diphosphochitobiose to Enable Protein N ‐Glycosylation Studies. Helvetica chimica acta, 106(12) Wiley 10.1002/hlca.202300171

Orsi, Markus; Probst, Daniel; Schwaller, Philippe; Reymond, Jean-Louis (2023). Alchemical analysis of FDA approved drugs. Digital discovery, 2(5), pp. 1289-1296. Royal Society of Chemistry 10.1039/d3dd00039g

Georgiou, Christos D; McKay, Christopher; Reymond, Jean-Louis (2023). Organic Catalytic Activity as a Method for Agnostic Life Detection. Astrobiology, 23(10), pp. 1118-1127. Mary Ann Liebert 10.1089/ast.2023.0022

Kreutter, David; Reymond, Jean-Louis (2023). Multistep retrosynthesis combining a disconnection aware triple transformer loop with a route penalty score guided tree search. Chemical Science, 14(36), pp. 9959-9969. The Royal Society of Chemistry 10.1039/d3sc01604h

Cai, Xingguang; Capecchi, Alice; Olcay, Başak; Orsi, Markus; Javor, Sacha; Reymond, Jean-Louis (2023). Exploring the Sequence Space of Antimicrobial Peptide Dendrimers. Israel journal of chemistry, 63(10-11) Wiley-VCH 10.1002/ijch.202300096

Personne, Hippolyte; Paschoud, Thierry; Fulgencio, Sofia; Baeriswyl, Stéphane; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Javor, Sacha; Reymond, Jean-Louis (2023). To Fold or Not to Fold: Diastereomeric Optimization of an α-Helical Antimicrobial Peptide. Journal of medicinal chemistry, 66(11), pp. 7570-7583. American Chemical Society 10.1021/acs.jmedchem.3c00460

Bloch, Joël S; John, Alan; Mao, Runyu; Mukherjee, Somnath; Boilevin, Jérémy; Irobalieva, Rossitza N; Darbre, Tamis; Scott, Nichollas E; Reymond, Jean-Louis; Kossiakoff, Anthony A; Goddard-Borger, Ethan D; Locher, Kaspar P (2023). Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nature chemical biology, 19(5), pp. 575-584. Springer Nature 10.1038/s41589-022-01219-9

De Capitani, Mario M.; Ramírez, Ana S.; Rossi, Lorenzo; Alexander, J. Andrew N.; De Lorenzo, Sabrina; Locher, Kaspar P.; Reymond, Jean-Louis (2023). Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation. Tetrahedron, 136, p. 133361. Elsevier Science 10.1016/j.tet.2023.133361

Bonvin, Etienne; Reymond, Jean-Louis (2023). Inverse Polyamidoamine (i‐PAMAM) Dendrimer Antimicrobials. Helvetica chimica acta, 106(6) Wiley 10.1002/hlca.202300035

Personne, Hippolyte; Siriwardena, Thissa N; Javor, Sacha; Reymond, Jean-Louis (2023). Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis. ACS Omega, 8(5), pp. 5050-5056. American Chemical Society 10.1021/acsomega.2c07861

Buehler, Ye; Reymond, Jean-Louis (2023). Molecular Framework Analysis of the Generated Database GDB-13s. Journal of chemical information and modeling, 63(2), pp. 484-492. American Chemical Society 10.1021/acs.jcim.2c01107

Cai, Xingguang; Orsi, Markus; Capecchi, Alice; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2022). An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening. Cell reports. Physical science, 3(12), pp. 1-15. Cell Press 10.1016/j.xcrp.2022.101161

Abriel, Hugues; Reymond, Jean-Louis (2022). NCCR TransCure - Excellence in Membrane Transport Research from 2010 until 2022. CHIMIA, 76(12), p. 989. Schweizerische Chemische Gesellschaft

Ramírez, Ana S; De Capitani, Mario; Pesciullesi, Giorgio; Kowal, Julia; Bloch, Joël S; Irobalieva, Rossitza N; Reymond, Jean-Louis; Aebi, Markus; Locher, Kaspar P (2022). Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase. Nature communications, 13(1), p. 7296. Nature Publishing Group 10.1038/s41467-022-35067-x

Morstein, Johannes; Capecchi, Alice; Hinnah, Konstantin; Park, ByungUk; Petit-Jacques, Jerome; Van Lehn, Reid C; Reymond, Jean-Louis; Trauner, Dirk (2022). Medium-Chain Lipid Conjugation Facilitates Cell-Permeability and Bioactivity. Journal of the American Chemical Society, 144(40), pp. 18532-18544. American Chemical Society 10.1021/jacs.2c07833

Zhu, Di; Johannsen, Sandra; Masini, Tiziana; Simonin, Céline; Haupenthal, Jörg; Illarionov, Boris; Andreas, Anastasia; Awale, Mahendra; Gierse, Robin M; van der Laan, Tridia; van der Vlag, Ramon; Nasti, Rita; Poizat, Mael; Buhler, Eric; Reiling, Norbert; Müller, Rolf; Fischer, Markus; Reymond, Jean-Louis; Hirsch, Anna K H (2022). Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening. Chemical Science, 13(36), pp. 10686-10698. The Royal Society of Chemistry 10.1039/d2sc02371g

Zakharova, Elena; Orsi, Markus; Capecchi, Alice; Reymond, Jean-Louis (2022). Machine Learning Guided Discovery of Non-Hemolytic Membrane Disruptive Anti-Cancer Peptides. ChemMedChem, 17(17), e202200291. Wiley-VCH 10.1002/cmdc.202200291

Probst, Daniel; Schwaller, Philippe; Reymond, Jean-Louis (2022). Reaction classification and yield prediction using the differential reaction fingerprint DRFP. Digital discovery, 1(2), pp. 91-97. Royal Society of Chemistry 10.1039/d1dd00006c

Pujol-Giménez, Jonai; Poirier, Marion; Bühlmann, Sven; Schuppisser, Céline; Bhardwaj, Rajesh; Awale, Mahendra; Visini, Ricardo; Javor, Sacha; Hediger, Matthias; Reymond, Jean-Louis (2021). Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB-17 Fragment Library. ChemMedChem, 16(21), pp. 3306-3314. Wiley-VCH 10.1002/cmdc.202100467

Capecchi, Alice; Reymond, Jean-Louis (2021). Classifying natural products from plants, fungi or bacteria using the COCONUT database and machine learning. Journal of cheminformatics, 13(82), p. 1069. Springer 10.1186/s13321-021-00559-3

Erzina, Dina; Capecchi, Alice; Javor, Sacha; Reymond, Jean-Louis (2021). An Immunomodulatory Peptide Dendrimer Inspired from Glatiramer Acetate. Angewandte Chemie International Edition, 60(50), pp. 26403-26408. Wiley 10.1002/anie.202113562

Baeriswyl, Stéphane; Personne, Hippolyte; Di Bonaventura, Ivan; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Javor, Sacha; Reymond, Jean-Louis (2021). A mixed chirality α-helix in a stapled bicyclic and a linear antimicrobial peptide revealed by X-ray crystallography. RSC chemical biology, 2(6), pp. 1608-1617. Royal Society of Chemistry 10.1039/D1CB00124H

Jafari, Paris; Luscher, Alexandre; Siriwardena, Thissa; Michetti, Murielle; Que, Yok-Ai; Rahme, Laurence G.; Reymond, Jean-Louis; Raffoul, Wassim; Van Delden, Christian; Applegate, Lee Ann; Köhler, Thilo (2021). Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns. Molecules, 26(13), p. 3839. MDPI 10.3390/molecules26133839

Capecchi, Alice; Cai, Xingguang; Personne, Hippolyte; Köhler, Thilo; van Delden, Christian; Reymond, Jean-Louis (2021). Machine learning designs non-hemolytic antimicrobial peptides. Chemical Science, 12(26), pp. 9221-9232. The Royal Society of Chemistry 10.1039/D1SC01713F

Reymond, Jean-Louis (2021). Peptide Dendrimers: From Enzyme Models to Antimicrobials and Transfection Reagents. CHIMIA, 75(6), pp. 535-538. Schweizerische Chemische Gesellschaft 10.2533/chimia.2021.535

Kreutter, David; Schwaller, Philippe; Reymond, Jean-Louis (2021). Predicting enzymatic reactions with a molecular transformer. Chemical Science, 12(25), pp. 8648-8659. The Royal Society of Chemistry 10.1039/D1SC02362D

Eyring, Jillianne; Lin, Chia-Wei; Ngwa, Elsy Mankah; Boilevin, Jérémy; Pesciullesi, Giorgio; Locher, Kaspar P.; Darbre, Tamis; Reymond, Jean-Louis; Aebi, Markus (2021). Substrate specificities and reaction kinetics of the yeast oligosaccharyltransferase isoforms. Journal of biological chemistry, 296, p. 100809. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2021.100809

Cai, Xingguang; Javor, Sacha; Gan, Bee Ha; Köhler, Thilo; Reymond, Jean-Louis (2021). The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4. Chemical communications, 57(46), pp. 5654-5657. Royal Society of Chemistry 10.1039/D1CC01838H

Schwaller, Philippe; Hoover, Benjamin; Reymond, Jean-Louis; Strobelt, Hendrik; Laino, Teodoro (2021). Extraction of organic chemistry grammar from unsupervised learning of chemical reactions. Science Advances, 7(15) American Association for the Advancement of Science 10.1126/sciadv.abe4166

Schwaller, Philippe; Vaucher, Alain C; Laino, Teodoro; Reymond, Jean-Louis (2021). Prediction of chemical reaction yields using deep learning. Machine learning: science and technology, 2(1), 015016. IOP Publishing 10.1088/2632-2153/abc81d

Reymond, Jean-Louis; Auberson, Yves P.; Benfatti, Fides; Zumbrunn, Cornelia (2021). Medicinal Chemistry and Chemical Biology in the Age of the Pandemic. CHIMIA, 75(3), pp. 225-226. Schweizerische Chemische Gesellschaft 10.2533/chimia.2021.225

Schwaller, Philippe; Probst, Daniel; Vaucher, Alain C.; Nair, Vishnu H.; Kreutter, David Patrick Joseph; Laino, Teodoro; Reymond, Jean-Louis (2021). Mapping the space of chemical reactions using attention-based neural networks. Nature machine intelligence, 3(2), pp. 144-152. Springer Nature 10.1038/s42256-020-00284-w

Thakkar, Amol; Chadimová, Veronika; Bjerrum, Esben Jannik; Engkvist, Ola; Reymond, Jean-Louis (2021). Retrosynthetic accessibility score (RAscore) – rapid machine learned synthesizability classification from AI driven retrosynthetic planning. Chemical Science, 12(9), pp. 3339-3349. The Royal Society of Chemistry 10.1039/D0SC05401A

Siriwardena, Thissa N.; Gan, Bee-Ha; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2021). Stereorandomization as a Method to Probe Peptide Bioactivity. ACS central science, 7(1), pp. 126-134. ACS Publications 10.1021/acscentsci.0c01135

Daralnakhla, Haneen; Saher, Osama; Zamolo, Susanna; Bazaz, Safa; P. Bost, Jeremy; Heitz, Marc; Lundin, Karin E.; EL Andaloussi, Samir; Darbre, Tamis; Reymond, Jean-Louis; Zain, Rula; Smith, C. I. Edvard (2021). Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides. Pharmaceutics, 13(1), p. 116. MDPI 10.3390/pharmaceutics13010116

Capecchi, Alice; Reymond, Jean-Louis (2021). Peptides in chemical space. Medicine in drug discovery, 9, p. 100081. Elsevier 10.1016/j.medidd.2021.100081

Meier, Kris; Arús-Pous, Josep; Reymond, Jean-Louis (2021). A Potent and Selective Janus Kinase Inhibitor with a Chiral 3D‐Shaped Triquinazine Ring System from Chemical Space. Angewandte Chemie (International ed.), 60(4), pp. 2074-2077. Wiley-VCH 10.1002/anie.202012049

Thakkar, Amol; Johansson, Simon; Jorner, Kjell; Buttar, David; Reymond, Jean-Louis; Engkvist, Ola (2021). Artificial intelligence and automation in computer aided synthesis planning. Reaction chemistry & engineering, 6(1), pp. 27-51. Royal Society of Chemistry 10.1039/D0RE00340A

Gan, Bee-Ha; Cai, Xingguang; Javor, Sacha; Köhler, Thilo; Reymond, Jean-Louis (2020). Synergistic Effect of Propidium Iodide and Small Molecule Antibiotics with the Antimicrobial Peptide Dendrimer G3KL against Gram-Negative Bacteria. Molecules, 25(23), p. 5643. MDPI 10.3390/molecules25235643

Bhardwaj, Rajesh; Lindinger, Sonja; Neuberger, Arthur; Nadezhdin, Kirill D.; Singh, Appu K.; R. Cunha, Micael; Derler, Isabella; Gyimesi, Gergely; Reymond, Jean-Louis; Hediger, Matthias A.; Romanin, Christoph; Sobolevsky, Alexander I. (2020). Inactivation-mimicking block of the epithelial calcium channel TRPV6. Science Advances, 6(48), eabe1508. American Association for the Advancement of Science 10.1126/sciadv.abe1508

Genheden, Samuel; Thakkar, Amol; Chadimová, Veronika; Reymond, Jean-Louis; Engkvist, Ola; Bjerrum, Esben (2020). AiZynthFinder: a fast, robust and flexible open-source software for retrosynthetic planning. Journal of cheminformatics, 12(1) Springer 10.1186/s13321-020-00472-1

Fitzner, Martin; Wuitschik, Georg; Koller, Raffael J.; Adam, Jean-Michel; Schindler, Torsten; Reymond, Jean-Louis (2020). What can reaction databases teach us about Buchwald–Hartwig cross-couplings? Chemical Science, 11(48), pp. 13085-13093. The Royal Society of Chemistry 10.1039/d0sc04074f

Capecchi, Alice; Reymond, Jean-Louis (2020). Assigning the Origin of Microbial Natural Products by Chemical Space Map and Machine Learning. Biomolecules, 10(10), p. 1385. MDPI 10.3390/biom10101385

Pesciullesi, Giorgio; Schwaller, Philippe; Laino, Teodoro; Reymond, Jean-Louis (2020). Transfer learning enables the molecular transformer to predict regio- and stereoselective reactions on carbohydrates. Nature Communications, 11(1) Springer Nature 10.1038/s41467-020-18671-7

Rodrigues Cunha, Micael; Bhardwaj, Rajesh; Carrel, Aline Lucie; Lindinger, Sonja; Romanin, Christoph; Parise-Filho, Roberto; Hediger, Matthias A.; Reymond, Jean-Louis (2020). Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor. RSC Medicinal Chemistry, 11(9), pp. 1032-1040. Royal Society of Chemistry 10.1039/D0MD00145G

Stoklosa, Paulina; Probst, Daniel; Reymond, Jean-Louis; Peinelt, Christine (2020). The name tells the story: Two-pore channels. Cell calcium, 89, p. 102215. Elsevier 10.1016/j.ceca.2020.102215

Capecchi, Alice; Probst, Daniel; Reymond, Jean-Louis (2020). One molecular fingerprint to rule them all: drugs, biomolecules, and the metabolome. Journal of cheminformatics, 12(1) Springer 10.1186/s13321-020-00445-4

Poirier, Marion; Pujol-Giménez, Jonai; Manatschal, Cristina; Bühlmann, Sven; Embaby, Ahmed; Javor, Sacha; Hediger, Matthias A.; Reymond, Jean-Louis (2020). Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation. RSC Medicinal Chemistry, 11(9), pp. 1023-1031. Royal Society of Chemistry 10.1039/D0MD00085J

Arús-Pous, Josep; Patronov, Atanas; Bjerrum, Esben Jannik; Tyrchan, Christian; Reymond, Jean-Louis; Chen, Hongming; Engkvist, Ola (2020). SMILES-based deep generative scaffold decorator for de-novo drug design. Journal of cheminformatics, 12(1) Springer 10.1186/s13321-020-00441-8

Heitz, Marc; Zamolo, Susanna; Javor, Sacha; Reymond, Jean-Louis (2020). Fluorescent Peptide Dendrimers for siRNA Transfection: Tracking pH Responsive Aggregation, siRNA Binding, and Cell Penetration. Bioconjugate chemistry, 31(6), pp. 1671-1684. American Chemical Society 10.1021/acs.bioconjchem.0c00231

Thakkar, Amol; Selmi, Nidhal; Reymond, Jean-Louis; Engkvist, Ola; Bjerrum, Esben Jannik (2020). “Ring Breaker”: Neural Network Driven Synthesis Prediction of the Ring System Chemical Space. Journal of medicinal chemistry, 63(16), pp. 8791-8808. American Chemical Society 10.1021/acs.jmedchem.9b01919

Meier, Kris; Bühlmann, Sven; Arús-Pous, Josep; Reymond, Jean-Louis (2020). The Generated Databases (GDBs) as a Source of 3D-shaped Building Blocks for Use in Medicinal Chemistry and Drug Discovery. CHIMIA, 74(4), pp. 241-246. Schweizerische Chemische Gesellschaft 10.2533/chimia.2020.241

Bloch, Joël S.; Pesciullesi, Giorgio; Boilevin, Jérémy; Nosol, Kamil; Irobalieva, Rossitza N.; Darbre, Tamis; Aebi, Markus; Kossiakoff, Anthony A.; Reymond, Jean-Louis; Locher, Kaspar P. (2020). Structure and mechanism of the ER-based glucosyltransferase ALG6. Nature, 579(7799), pp. 443-447. Springer Nature 10.1038/s41586-020-2044-z

Probst, Daniel; Reymond, Jean-Louis (2020). Visualization of very large high-dimensional data sets as minimum spanning trees. Journal of cheminformatics, 12(1) Springer 10.1186/s13321-020-0416-x

Bühlmann, Sven; Reymond, Jean-Louis (2020). ChEMBL-Likeness Score and Database GDBChEMBL. Frontiers in Chemistry, 8(46) Frontiers Media 10.3389/fchem.2020.00046

Ben Jeddou, Fatma; Falconnet, Léna; Luscher, Alexandre; Siriwardena, Thissa; Reymond, Jean-Louis; van Delden, Christian; Köhler, Thilo (2020). Adaptive and Mutational Responses to Peptide Dendrimer Antimicrobials in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 64(4) American Society for Microbiology 10.1128/AAC.02040-19

Capecchi, Alice; Zhang, Alain; Reymond, Jean-Louis (2020). Populating Chemical Space with Peptides Using a Genetic Algorithm. Journal of chemical information and modeling, 60(1), pp. 121-132. American Chemical Society 10.1021/acs.jcim.9b01014

Thakkar, Amol; Kogej, Thierry; Reymond, Jean-Louis; Engkvist, Ola; Bjerrum, Esben Jannik (2020). Datasets and their influence on the development of computer assisted synthesis planning tools in the pharmaceutical domain. Chemical Science, 11(1), pp. 154-168. The Royal Society of Chemistry 10.1039/C9SC04944D

Zamolo, Susanna J.; Darbre, Tamis; Reymond, Jean-Louis (2020). Transfecting tissue models with CRISPR/Cas9 plasmid DNA using peptide dendrimers. Chemical communications, 56(80), pp. 11981-11984. Royal Society of Chemistry 10.1039/D0CC04750C

Manatschal, Cristina; Pujol-Giménez, Jonai; Poirier, Marion; Reymond, Jean-Louis; Hediger, Matthias A.; Dutzler, Raimund (2019). Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds. eLife, 8 eLife Sciences Publications 10.7554/eLife.51913

Arús-Pous, Josep; Awale, Mahendra; Probst, Daniel; Reymond, Jean-Louis (2019). Exploring Chemical Space with Machine Learning. CHIMIA, 73(12), pp. 1018-1023. Schweizerische Chemische Gesellschaft 10.2533/chimia.2019.1018

R. Cunha, Micael; Bhardwaj, Rajesh; Lindinger, Sonja; Butorac, Carmen; Romanin, Christoph; Hediger, Matthias; Reymond, Jean-Louis (2019). Photoswitchable Inhibitor of the Calcium Channel TRPV6. ACS medicinal chemistry letters, 10(9), pp. 1341-1345. American Chemical Society 10.1021/acsmedchemlett.9b00298

Delalande, Clémence; Awale, Mahendra; Rubin, Matthias; Probst, Daniel; Ozhathil, Lijo C.; Gertsch, Jürg; Abriel, Hugues; Reymond, Jean-Louis (2019). Optimizing TRPM4 inhibitors in the MHFP6 chemical space. European journal of medicinal chemistry, 166, pp. 167-177. Elsevier 10.1016/j.ejmech.2019.01.048

Awale, Mahendra; Reymond, Jean-Louis (2019). The Polypharmacology Browser PPB2: Target Prediction Combining Nearest Neighbors with Machine Learning. Journal of chemical information and modeling, 59(1), pp. 10-17. American Chemical Society 10.1021/acs.jcim.8b00524

Siriwardena, Thissa N.; Lüscher, Alexandre; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2019). Antimicrobial Peptide Dendrimer Chimera. Helvetica chimica acta, 102(4), e1900034. Wiley 10.1002/hlca.201900034

Baeriswyl, Stéphane; Gan, Bee Ha; Siriwardena, Thissa N.; Visini, Ricardo; Robadey, Maurane; Javor, Sacha; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2019). X-ray Crystal Structures of Short Antimicrobial Peptides as Pseudomonas aeruginosa Lectin B Complexes. ACS Chemical Biology, 14(4), pp. 758-766. American Chemical Society 10.1021/acschembio.9b00047

Capecchi, Alice; Awale, Mahendra; Probst, Daniel; Reymond, Jean-Louis (2019). PubChem and ChEMBL beyond Lipinski. Molecular informatics, 38(5), p. 1900016. Wiley 10.1002/minf.201900016

Arús-Pous, Josep; Blaschke, Thomas; Ulander, Silas; Reymond, Jean-Louis; Chen, Hongming; Engkvist, Ola (2019). Exploring the GDB-13 chemical space using deep generative models. Journal of cheminformatics, 11(1), p. 20. Springer 10.1186/s13321-019-0341-z

Morstein, Johannes; Awale, Mahendra; Reymond, Jean-Louis; Trauner, Dirk (2019). Mapping the Azolog Space Enables the Optical Control of New Biological Targets. ACS central science, 5(4), pp. 607-618. ACS Publications 10.1021/acscentsci.8b00881

Awale, Mahendra; Sirockin, Finton; Stiefl, Nikolaus; Reymond, Jean-Louis (2019). Drug Analogs from Fragment-Based Long Short-Term Memory Generative Neural Networks. Journal of chemical information and modeling, 59(4), pp. 1347-1356. American Chemical Society 10.1021/acs.jcim.8b00902

Awale, Mahendra; Sirockin, Finton; Stiefl, Nikolaus; Reymond, Jean-Louis (2019). Medicinal Chemistry Aware Database GDBMedChem. Molecular informatics, 38(8-9), p. 1900031. Wiley 10.1002/minf.201900031

Arús-Pous, Josep; Johansson, Simon Viet; Prykhodko, Oleksii; Bjerrum, Esben Jannik; Tyrchan, Christian; Reymond, Jean-Louis; Chen, Hongming; Engkvist, Ola (2019). Randomized SMILES strings improve the quality of molecular generative models. Journal of cheminformatics, 11(1) Springer 10.1186/s13321-019-0393-0

Heitz, Marc; Javor, Sacha; Darbre, Tamis; Reymond, Jean-Louis (2019). Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection. Bioconjugate chemistry, 30(8), pp. 2165-2182. American Chemical Society 10.1021/acs.bioconjchem.9b00403

Baeriswyl, Stéphane; Javor, Sacha; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2019). X‐Ray Crystal Structure of a Second‐Generation Peptide Dendrimer in Complex with Pseudomonas aeruginosa Lectin LecB. Helvetica chimica acta, 102(9) Wiley 10.1002/hlca.201900178

Taouai, Marwa; Chakroun, Khouloud; Sommer, Roman; Michaud, Gaelle; Giacalone, David; Ben Maaouia, Mohamed Amine; Vallin-Butruille, Aurélie; Mathiron, David; Abidi, Rym; Darbre, Tamis; Cragg, Peter J.; Mullié, Catherine; Reymond, Jean-Louis; O’Toole, George A.; Benazza, Mohammed (2019). Glycocluster Tetrahydroxamic Acids Exhibiting Unprecedented Inhibition of Pseudomonas aeruginosa Biofilms. Journal of medicinal chemistry, 62(17), pp. 7722-7738. American Chemical Society 10.1021/acs.jmedchem.9b00481

Gan, Bee Ha; Siriwardena, Thissa N.; Javor, Sacha; Darbre, Tamis; Reymond, Jean-Louis (2019). Fluorescence Imaging of Bacterial Killing by Antimicrobial Peptide Dendrimer G3KL. ACS infectious diseases, 5(12), pp. 2164-2173. American Chemical Society 10.1021/acsinfecdis.9b00299

Han, Xiao; Liu, Yujie; Ma, Yibing; Zhang, Mengqing; He, Zhengjin; Siriwardena, Thissa N.; Xu, Haijin; Bai, Yanling; Zhang, Xiuming; Reymond, Jean-Louis; Qiao, Mingqiang (2019). Peptide dendrimers G3KL and TNS18 inhibit Pseudomonas aeruginosa biofilms. Applied microbiology and biotechnology, 103(14), pp. 5821-5830. Springer 10.1007/s00253-019-09801-3

Probst, Daniel; Reymond, Jean-Louis (2018). A probabilistic molecular fingerprint for big data settings. Journal of cheminformatics, 10(1) BioMed Central 10.1186/s13321-018-0321-8

Poirier, Marion; Awale, Mahendra; Rölli, Matthias A.; Giuffredi, Guy T.; Ruddigkeit, Lars; Evensen, Lasse; Stooss, Amandine; Calarco, Serafina; Lorens, James B.; Charles, Roch-Philippe; Reymond, Jean-Louis (2018). Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT-β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2. ChemMedChem, 14(2), pp. 224-236. Wiley-VCH 10.1002/cmdc.201800554

Napiórkowska, Maja; Boilevin, Jérémy; Darbre, Tamis; Reymond, Jean-Louis; Locher, Kaspar P. (2018). Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide. Scientific Reports, 8(1) Nature Publishing Group 10.1038/s41598-018-34534-0

Pompilio, Arianna; Geminiani, Cristina; Mantini, Paolo; Siriwardena, Thissa N.; Di Bonaventura, Ivan; Reymond, Jean Louis; Di Bonaventura, Giovanni (2018). Peptide dendrimers as “lead compounds” for the treatment of chronic lung infections by Pseudomonas aeruginosa in cystic fibrosis patients: in vitro and in vivo studies. Infection and drug resistance, 11, pp. 1767-1782. Dove Medical Press 10.2147/IDR.S168868

Saher, Osama; Rocha, Cristina S.J.; Zaghloul, Eman M.; Wiklander, Oscar P.B.; Zamolo, Susanna; Heitz, Marc; Ezzat, Kariem; Gupta, Dhanu; Reymond, Jean-Louis; Zain, Rula; Hollfelder, Florian; Darbre, Tamis; Lundin, Karin E.; EL Andaloussi, Samir; Smith, C.I. Edvard (2018). Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity. European journal of pharmaceutics and biopharmaceutics, 132, pp. 29-40. Elsevier 10.1016/j.ejpb.2018.09.002

Probst, Daniel; Reymond, Jean-Louis (2018). Exploring DrugBank in Virtual Reality Chemical Space. Journal of chemical information and modeling, 58(9), pp. 1731-1735. American Chemical Society 10.1021/acs.jcim.8b00402

Boilevin, Jérémy M.; Reymond, Jean-Louis (2018). Synthesis of Lipid-Linked Oligosaccharides (LLOs) and Their Phosphonate Analogues as Probes To Study Protein Glycosylation Enzymes. Synthesis - journal of synthetic organic chemistry, 50(14), pp. 2631-2654. Thieme 10.1055/s-0037-1609735

Ozhathil, Lijo Cherian; Delalande, Clémence Marie Sandrine; Bianchi, Beatrice; Nemeth, Gabor; Kappel, Sven; Thomet, Urs; Ross, Daniela; Simonin, Céline; Rubin, Matthias; Gertsch, Jürg; Lochner, Martin; Peinelt, Christine; Reymond, Jean-Louis; Abriel, Hugues (2018). Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. British journal of pharmacology, 175(12), pp. 2504-2519. Wiley-Blackwell 10.1111/bph.14220

Siriwardena, Thissa N.; Capecchi, Alice; Gan, Bee-Ha; Jin, Xian; He, Runze; Wei, Dengwen; Ma, Lan; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2018). Optimizing Antimicrobial Peptide Dendrimers in Chemical Space. Angewandte Chemie (International ed.), 57(28), pp. 8483-8487. Wiley-VCH 10.1002/anie.201802837

Di Bonaventura, Ivan; Baeriswyl, Stéphane; Capecchi, Alice; Gan, Bee-Ha; Jin, Xian; Siriwardena, Thissa N.; He, Runze; Köhler, Thilo; Pompilio, Arianna; Di Bonaventura, Giovanni; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2018). An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria. Chemical communications, 54(40), pp. 5130-5133. Royal Society of Chemistry 10.1039/C8CC02412J

Probst, Daniel; Reymond, Jean-Louis (2018). FUn: A Framework for Interactive Visualizations of Large, High Dimensional Datasets on the Web. Bioinformatics, 34(8), pp. 1433-1435. Oxford University Press 10.1093/bioinformatics/btx760

Ramírez, Ana S.; Boilevin, Jérémy; Mehdipour, Ahmad Reza; Hummer, Gerhard; Darbre, Tamis; Reymond, Jean-Louis; Locher, Kaspar P. (2018). Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase. Nature communications, 9(1) Nature Publishing Group 10.1038/s41467-018-02880-2

Lin, Arkadii; Horvath, Dragos; Afonina, Valentina; Marcou, Gilles; Reymond, Jean-Louis; Varnek, Alexandre (2018). Mapping of the Available Chemical Space versus the Chemical Universe of Lead-Like Compounds. ChemMedChem, 13(6), pp. 540-554. Wiley-VCH 10.1002/cmdc.201700561

Siriwardena, Thissa Appuhamilage Nuwan; Stach, Michaela; He, Runze; Gan, Bee Ha; Javor, Sacha; Heitz, Marc; Ma, Lan; Cai, Xiangjun; Chen, Peng; Wei, Dengwen; Li, Hongtao; Ma, Jun; Koehler, Thilo; van Delden, Christian; Darbre, Tamis; Reymond, Jean-Louis (2018). Lipidated Peptide Dendrimers Killing Multidrug Resistant Bacteria. Journal of the American Chemical Society, 140(1), pp. 423-432. American Chemical Society 10.1021/jacs.7b11037

Probst, Daniel; Reymond, Jean-Louis (2018). SmilesDrawer: Parsing and Drawing SMILES-Encoded Molecular Structures Using Client-Side JavaScript. Journal of chemical information and modeling, 58(1), pp. 1-7. American Chemical Society 10.1021/acs.jcim.7b00425

Arús-Pous, Josep; Probst, Daniel; Reymond, Jean-Louis (2018). Deep Learning Invades Drug Design and Synthesis. CHIMIA, 72(1), pp. 70-71. Schweizerische Chemische Gesellschaft 10.2533/chimia.2018.70

Langron, Emily; Simone, Michela I; Delalande, Clémence Marie Sandrine; Reymond, Jean-Louis; Selwood, David L; Vergani, Paola (2017). Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds. British journal of pharmacology, 174(7), pp. 525-539. Wiley-Blackwell 10.1111/bph.13715

Ramírez, Ana S; Boilevin, Jérémy; Biswas, Rasomoy; Gan, Bee Ha; Janser, Daniel; Aebi, Markus; Darbre, Tamis; Reymond, Jean-Louis; Locher, Kaspar P (2017). Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides and lipid-linked oligosaccharide analogs. Glycobiology, 27(6), pp. 525-535. Oxford University Press 10.1093/glycob/cwx017

Awale, Mahendra; Reymond, Jean-Louis (2017). The polypharmacology browser: a web-based multi-fingerprint target prediction tool using ChEMBL bioactivity data. Journal of cheminformatics, 9(11), p. 11. BioMed Central 10.1186/s13321-017-0199-x

Awale, Mahendra; Probst, Daniel; Reymond, Jean-Louis (2017). WebMolCS: A Web-Based Interface for Visualizing Molecules in Three-Dimensional Chemical Spaces. Journal of chemical information and modeling, 57(4), pp. 643-649. American Chemical Society 10.1021/acs.jcim.6b00690

Visini, Ricardo; Awale, Mahendra; Reymond, Jean-Louis (2017). Fragment Database FDB-17. Journal of chemical information and modeling, 57(4), pp. 700-709. American Chemical Society 10.1021/acs.jcim.7b00020

Heitz, Marc; Kwok, Albert; Eggimann, GabrielaA.; Hollfelder, Florian; Darbre, Tamis; Reymond, Jean-Louis (2017). Peptide Dendrimer–Lipid Conjugates as DNA and siRNA Transfection Reagents: Role of Charge Distribution Across Generations. CHIMIA, 71(4), pp. 220-225. Schweizerische Chemische Gesellschaft 10.2533/chimia.2017.220

Ramírez, Ana S; Boilevin, Jérémy; Lin, Chia-Wei; Gan, Bee Ha; Janser, Daniel; Aebi, Markus; Darbre, Tamis; Reymond, Jean-Louis; Locher, Kaspar P (2017). Chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins. Glycobiology, 27(8), pp. 726-733. Oxford University Press 10.1093/glycob/cwx045

Di Bonaventura, Ivan; Jin, Xian; Visini, Ricardo; Probst, Daniel; Javor, Sacha; Gan, Bee-Ha; Michaud, Gaëlle; Natalello, Antonino; Doglia, Silvia Maria; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2017). Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms. Chemical Science, 8(10), pp. 6784-6798. The Royal Society of Chemistry 10.1039/C7SC01314K

He, Runze; Di Bonaventura, Ivan; Visini, Ricardo; Gan, Bee-Ha; Fu, Yongchun; Probst, Daniel; Lüscher, Alexandre; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Hong, Wenjing; Darbre, Tamis; Reymond, Jean-Louis (2017). Design, crystal structure and atomic force microscopy study of thioether ligated d , l -cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa. Chemical Science, 8(11), pp. 7464-7475. The Royal Society of Chemistry 10.1039/C7SC01599B

Sebastián-Pérez, Víctor; Roca, Carlos; Awale, Mahendra; Reymond, Jean-Louis; Martinez, Ana; Gil, Carmen; Campillo, Nuria E. (2017). Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits. Journal of chemical information and modeling, 57(9), pp. 2143-2151. American Chemical Society 10.1021/acs.jcim.7b00401

Probst, Daniel; Heitz, Marc; Poirier, Marion; Gan, Bee Ha; Delalande, Clémence Marie Sandrine; Reymond, Jean-Louis (2017). Frontiers in Medicinal Chemistry 2017 in Bern, Switzerland. ChemMedChem, 12(19), pp. 1645-1651. Wiley-VCH 10.1002/cmdc.201700306

Visini, Ricardo; Arus Pous, Josep; Awale, Mahendra; Reymond, Jean-Louis (2017). Virtual Exploration of the Ring Systems Chemical Universe. Journal of chemical information and modeling, 57(11), pp. 2707-2718. American Chemical Society 10.1021/acs.jcim.7b00457

Napiórkowska, Maja; Boilevin, Jérémy; Sovdat, Tina; Darbre, Tamis; Reymond, Jean-Louis; Aebi, Markus; Locher, Kaspar P (2017). Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase. Nature structural & molecular biology, 24(12), pp. 1100-1106. Nature Publishing Group 10.1038/nsmb.3491

Awale, Mahendra; Visini, Ricardo; Probst, Daniel; Arus Pous, Josep; Reymond, Jean-Louis (2017). Chemical Space: Big Data Challenge for Molecular Diversity. CHIMIA, 71(10), pp. 661-666. Schweizerische Chemische Gesellschaft 10.2533/chimia.2017.661

Kilchmann, Falco; Marcaida, Maria; Sachin, Kotak; Schick, Thomas; Boss, Silvan; Awale, Mahendra; Gönczy, Pierre; Reymond, Jean-Louis (2016). Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening. Journal of medicinal chemistry, 59(15), pp. 7188-7211. American Chemical Society 10.1021/acs.jmedchem.6b00709

Röthlisberger, Pascal; Istrate, Alena; Marcaida Lopez, M. J.; Visini, Ricardo; Stocker, Achim; Reymond, Jean-Louis; Leumann, Christian (2016). X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair. Chemical communications, 52(26), pp. 4749-4752. Royal Society of Chemistry 10.1039/c6cc00374e

Michaud, Gaëlle; Visini, Ricardo; Bergman, Manfred Max; Salerno, Gianluca; Bosco, Rosa; Gillon, Emilie; Richichi, Barbara; Nativi, Cristina; Imberty, Anne; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2016). Overcoming antibiotic resistance in Pseudomonas aeruginosa biofilms using glycopeptide dendrimers. Chemical Science, 7(1), pp. 166-182. The Royal Society of Chemistry 10.1039/c5sc03635f

Awale, Mahendra; Reymond, Jean-Louis (2016). Web-based 3D-visualization of the DrugBank chemical space. Journal of cheminformatics, 8, p. 25. Springer 10.1186/s13321-016-0138-2

Kwok, Albert; Eggimann, Gabriela A.; Heitz, Marc; Reymond, Jean-Louis; Hollfelder, Florian; Darbre, Tamis (2016). Efficient Transfection of siRNA by Peptide Dendrimer-Lipid Conjugates. ChemBioChem, 17(23), pp. 2223-2229. Wiley-VCH 10.1002/cbic.201600485

Tetko, Igor V.; Engkvist, Ola; Koch, Uwe; Reymond, Jean-Louis; Chen, Hongming (2016). BIGCHEM: Challenges and Opportunities for Big Data Analysis in Chemistry. Molecular informatics, 35(11-12), pp. 615-621. Wiley 10.1002/minf.201600073

Bürgi, Justus; Bertrand, Sonia; Marger, Fabrice; Bertrand, Daniel; Reymond, Jean-Louis (2016). Fluorescent Agonists of the α 7 Nicotinic Acetylcholine Receptor Derived from 3-Amino-Quinuclidine. Helvetica chimica acta, 99(10), pp. 790-804. Verlag Helvetica Chimica Acta 10.1002/hlca.201600120

Abdel-Sayed, Philippe; Kaeppli, Ariane; Siriwardena, Thissa; Darbre, Tamis; Perron, Karl; Jafari, Paris; Reymond, Jean-Louis; Pioletti, Dominique P.; Applegate, Lee Ann (2016). Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages. Scientific Reports, 6(22020), p. 22020. Nature Publishing Group 10.1038/srep22020

Pires, João; Siriwardena, Thissa N.; Stach, Michaela; Tinguely, Regula; Kasraian Fard, Sara; Luzzaro, Francesco; Leib, Stephen; Darbre, Tamis; Reymond, Jean-Louis; Endimiani, Andrea (2015). In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 59(12), pp. 7915-7918. American Society for Microbiology 10.1128/AAC.01853-15

Bergman, Manfred Max; Michaud, Gaëlle; Visini, Ricardo; Jin, Xian; Gillon, Emilie; Stocker, Achim; Imberty, Anne; Darbre, Tamis; Reymond, Jean-Louis (2015). Multivalency effects in Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA. Organic & biomolecular chemistry, 14(1), pp. 138-148. Royal Society of Chemistry 10.1039/C5OB01682G

Visini, Ricardo; Bergman, Manfred Max; Michaud, Gaelle; Pertici, Francesca; Fu, Ou; Pukin, Aliaksei; Branson, Thomas; Thies-Weesie, Dominique; Kemmink, Johan; Gillon, Emilie; Imberty, Anne; Stocker, Achim; Darbre, Tamis; Pieters, Roland; Reymond, Jean-Louis (2015). Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeroginosa lectin LecA. ACS Chemical Biology, 10(11), pp. 2455-2462. American Chemical Society 10.1021/acschembio.5b00302

González Salgado, Amaia; Steinmann, Michael Eduard; Major, Louise L; Sigel, Erwin; Reymond, Jean-Louis; Smith, Terry K; Bütikofer, Peter (2015). Trypanosoma brucei Bloodstream Forms Depend upon Uptake of myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth. Eukaryotic cell, 14(6), pp. 616-624. American Society for Microbiology ASM 10.1128/EC.00038-15

Giannini, Federico; Bartoloni, Marco; Paul, Lydia E. H.; Süss-Fink, Georg; Reymond, Jean-Louis; Furrer, Julien (2015). Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes. Medicinal chemistry communications - MedChemComm, 6(2), pp. 347-350. Royal Society of Chemistry 10.1039/c4md00433g

Jin, Xian; Awale, Mahendra; Zasso, Michaël; Kostro, Daniel; Patiny, Luc; Reymond, Jean-Louis (2015). PDB-Explorer: a web-based interactive map of the protein data bank in shape space. BMC bioinformatics, 16(1), 16:339. BioMed Central 10.1186/s12859-015-0776-9

Simonin, Céline; Awale, Mahendra; Brand, Michael; van Deursen, Ruud; Schwartz, Julian; Fine, Michael; Kovacs, Gergely; Häfliger, Pascal; Gyimesi, Gergely; Sithampari, Abilashan; Charles, Roch-Philippe; Hediger, Matthias; Reymond, Jean-Louis (2015). Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method. Angewandte Chemie (International ed.), 54(49), pp. 14748-14752. Wiley-VCH 10.1002/anie.201507320

Perez, Camilo; Gerber, Sabina; Boilevin, Jérémy; Bucher, Monika; Darbre, Tamis; Aebi, Markus; Reymond, Jean-Louis; Locher, Kaspar P. (2015). Structure and mechanism of an active lipid-linked oligosaccharide flippase. Nature, 524(7566), pp. 433-438. Macmillan Journals Ltd. 10.1038/nature14953

Awale, Mahendra; Reymond, Jean-Louis (2015). Similarity Mapplet: Interactive Visualization of the Directory of Useful Decoys and ChEMBL in High Dimensional Chemical Spaces. Journal of chemical information and modeling, 55(8), pp. 1509-1516. American Chemical Society 10.1021/acs.jcim.5b00182

Bartoloni, Marco; Jin, Xian; Marcaida, Maria José; Banha, João; Di Bonaventura, Ivan; Bongoni, Swathi; Bartho, Kathrin; Gräbner, Olivia; Sefkow, Michael; Darbre, Tamis; Reymond, Jean-Louis (2015). Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability. Chemical Science, 6(10), pp. 5473-5490. The Royal Society of Chemistry 10.1039/C5SC01699A

Reymond, Jean-Louis (2015). Articles of Significant Interest Selected from This Issue by the Editors. Eukaryotic cell, 14(6), p. 527. American Society for Microbiology ASM 10.1128/EC.00075-15

Montalbetti, Nicolas; Simonin, Alexandre; Simonin, Céline; Awale, Mahendra; Reymond, Jean-Louis; Hediger, Matthias (2015). Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2. Biochemical pharmacology, 96(3), pp. 216-224. Elsevier 10.1016/j.bcp.2015.05.002

Reymond, Jean-Louis (2015). The Chemical Space Project. Accounts of chemical research, 48(3), pp. 722-730. American Chemical Society 10.1021/ar500432k

Awale, Mahendra; Jin, Xian; Reymond, Jean-Louis (2015). Stereoselective virtual screening of the ZINC database using atom pair 3D-fingerprints. Journal of cheminformatics, 7(1), p. 3. Springer 10.1186/s13321-014-0051-5

Naegeli, A.; Michaud, Gaëlle; Schubert, M.; Lin, C.-W.; Lizak, C.; Darbre, Tamis; Reymond, Jean-Louis; Aebi, M. (2014). Substrate Specificity of Cytoplasmic N-Glycosyltransferase. Journal of biological chemistry, 289(35), pp. 24521-24532. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M114.579326

Awale, Mahendra; Reymond, Jean-Louis (2014). Atom Pair 2D-Fingerprints Perceive 3D-Molecular Shape and Pharmacophores for Very Fast Virtual Screening of ZINC and GDB-17. Journal of chemical information and modeling, 54(7), pp. 1892-1907. American Chemical Society 10.1021/ci500232g

Ruddigkeit, Lars; Awale, Mahendra; Reymond, Jean-Louis (2014). Expanding the fragrance chemical space for virtual screening. Journal of cheminformatics, 6(1), p. 27. Springer 10.1186/1758-2946-6-27

Bürgi, Justus; Awale, Mahendra; Boss, Silvan D.; Schaer, Tifany; Marger, Fabrice; Viveros Paredes, Juan Manuel; Bertrand, Sonia; Gertsch, Jürg; Bertrand, Daniel; Reymond, Jean-Louis (2014). Discovery of Potent Positive Allosteric Modulators of the α3β2 Nicotinic Acetylcholine Receptor by a Chemical Space Walk in ChEMBL. ACS chemical neuroscience, 5(5), pp. 346-359. American Chemical Society 10.1021/cn4002297

Awale, Mahendra; Reymond, Jean-Louis (2014). A multi-fingerprint browser for the ZINC database. Nucleic acids research, 42(W1), W234-W239. Information Retrieval Ltd. 10.1093/nar/gku379

Kouri, Tina M.; Awale, Mahendra; Slyby, James K.; Reymond, Jean-Louis; Mehta, Dinesh P. (2014). “Social” Network of Isomers Based on Bond Count Distance: Algorithms. Journal of chemical information and modeling, 54(1), pp. 57-68. American Chemical Society 10.1021/ci4005173

Bartoloni, Marco; Waltersperger, Sandro; Bumann, Mario; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2014). Stereoselective synthesis and structure determination of a bicyclo[3.3.2]decapeptide. Arkivoc, 2014(3), p. 113. Michigan Publishing 10.3998/ark.5550190.p008.500

Hari, Yvonne; Stucki, Silvan R.; Nyakas, Adrien; Blum, Lorenz; Reymond, Jean-Louis; Schürch, Stefan (2014). OMA & OPA – A Software Tool for Mass Spectrometric Sequencing of Nucleic Acids. CHIMIA, 68(1), p. 86. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2013.86

Stach, Michaela; Siriwardena, Thissa; Köhler, Thilo; van Delden, Christian; Darbre, Tamis; Reymond, Jean-Louis (2014). Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug-Resistant Pseudomonas aeruginosa. Angewandte Chemie (International ed.), 53(47), pp. 12827-12831. Wiley-VCH 10.1002/anie.201409270

Lizak, C.; Gerber, Sabine; Zinne, D.; Michaud, Gaëlle; Schubert, M.; Chen, F.; Bucherer, Monika; Darbre, Tamis; Zenobi, R.; Reymond, Jean-Louis; Locher, K. P. (2014). A Catalytically Essential Motif in External Loop 5 of the Bacterial Oligosaccharyltransferase PglB. Journal of biological chemistry, 289(2), pp. 735-746. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M113.524751

Eggimann, Gabriela A.; Blattes, Emilyne; Buschor, Stefanie; Biswas, Rasomoy; Kammer, Stephan M.; Darbre, Tamis; Reymond, Jean-Louis (2014). Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells. Chemical communications, 50(55), pp. 7254-7257. Royal Society of Chemistry 10.1039/C4CC02780A

Bernardi, Anna; Jiménez-Barbero, Jesus; Casnati, Alessandro; De Castro, Cristina; Darbre, Tamis; Fieschi, Franck; Finne, Jukka; Funken, Horst; Jaeger, Karl-Erich; Lahmann, Martina; Lindhorst, Thisbe K.; Marradi, Marco; Messner, Paul; Molinaro, Antonio; Murphy, Paul V.; Nativi, Cristina; Oscarson, Stefan; Penadés, Soledad; Peri, Francesco; Pieters, Roland J.; ... (2013). Multivalent glycoconjugates as anti-pathogenic agents. Chemical Society reviews, 42(11), pp. 4709-4727. Royal Society of Chemistry 10.1039/C2CS35408J

Nyakas, Adrien; Blum, Lorenz C.; Stucki, Silvan R.; Reymond, Jean-Louis; Schürch, Stefan (2013). OMA and OPA—Software-Supported Mass Spectra Analysis of Native and Modified Nucleic Acids. Journal of the American Society for Mass Spectrometry, 24(2), pp. 249-256. Springer-Verlag 10.1007/s13361-012-0529-1

Awale, Mahendra; van Deursen, Ruud; Reymond, Jean-Louis (2013). MQN-Mapplet: Visualization of Chemical Space with Interactive Maps of DrugBank, ChEMBL, PubChem, GDB-11, and GDB-13. Journal of chemical information and modeling, 53(2), pp. 509-518. American Chemical Society 10.1021/ci300513m

Geotti-Bianchini, Piero; Darbre, Tamis; Reymond, Jean-Louis (2013). pH-tuned metal coordination and peroxidase activity of a peptide dendrimer enzyme model with a Fe(ii)bipyridine at its core. Organic & biomolecular chemistry, 11(2), pp. 344-352. Royal Society of Chemistry 10.1039/c2ob26551f

Kadam, Rameshwar U.; Bergman, Manfred Max; Garg, Divita; Gabrieli, Gabriele; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2013). Structure-Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors of Pseudomonas aeruginosa Biofilms Targeting LecA. Chemistry - a European journal, 19(50), pp. 17054-17063. Wiley-VCH 10.1002/chem.201302587

Kadam, Rameshwar U.; Garg, Divita; Schwartz, Julian; Visini, Ricardo; Sattler, Michael; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2013). CH−π “T-Shape” Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa Lectin LecA. ACS Chemical Biology, 8(9), pp. 1925-1930. American Chemical Society 10.1021/cb400303w

Ravi, Harish Kumar; Stach, Michaela; Soares, Thereza; Darbre, Tamis; Reymond, Jean-Louis; Cascella, Michele (2013). Electrostatics and Flexibility Drive Membrane Recognition and Early Penetration by Antimicrobial Peptide Dendrimer bH1. Chemical communications, 49(78), pp. 8821-8823. Royal Society of Chemistry 10.1039/C3CC44912B

Ruddigkeit, Lars; Blum, Lorenz C.; Reymond, Jean-Louis (2013). Visualization and Virtual Screening of the Chemical Universe Database GDB-17. Journal of chemical information and modeling, 53(1), pp. 56-65. American Chemical Society 10.1021/ci300535x

Reymond, Jean-Louis; Bergman, Manfred Max; Darbre, Tamis (2013). Glycopeptide dendrimers as Pseudomonas aeruginosa biofilm inhibitors. Chemical Society reviews, 42(11), pp. 4814-4822. Royal Society of Chemistry 10.1039/c3cs35504g

Gerber, S.; Lizak, C.; Michaud, Gaëlle; Bucher, M.; Darbre, Tamis; Aebi, M.; Reymond, Jean-Louis; Locher, K. P. (2013). Mechanism of bacterial oligosaccharyltransferase: in vitro quantification of sequon binding and catalysis. Journal of biological chemistry, 288(13), pp. 8849-8861. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.445940

Heinisch, Tillmann; Langowska, Karolina; Tanner, Pascal; Reymond, Jean-Louis; Meier, Wolfgang; Palivan, Cornelia; Ward, Thomas R. (2013). Fluorescence-Based Assay for the Optimization of the Activity of Artificial Transfer Hydrogenase within a Biocompatible Compartment. ChemCatChem, 5(3), pp. 720-723. WILEY-VCH 10.1002/cctc.201200834

Kwok, Albert; Eggimann, Gabriela; Reymond, Jean-Louis; Darbre, Tamis; Hollfelder, Florian (2013). Peptide Dendrimer/Lipid Hybrid Systems Are Efficient DNA Transfection Reagents: Structure–Activity Relationships Highlight the Role of Charge Distribution Across Dendrimer Generations. ACS nano, 7(5), pp. 4668-4682. American Chemical Society 10.1021/nn400343z

Schwartz, Julian; Awale, Mahendra; Reymond, Jean-Louis (2013). SMIfp (SMILES fingerprint) Chemical Space for Virtual Screening and Visualization of Large Databases of Organic Molecules. Journal of chemical information and modeling, 53(8), pp. 1979-1989. American Chemical Society 10.1021/ci400206h

Eggimann, Gabriela; Buschor, Stefanie; Darbre, Tamis; Reymond, Jean-Louis (2013). Convergent synthesis and cellular uptake of multivalent cell penetrating peptides derived from Tat, Antp, pVEC, TP10 and SAP. Organic & biomolecular chemistry, 11(39), pp. 6717-6733. Royal Society of Chemistry 10.1039/c3ob41023d

Lizak, Christian; Gerber, Sabina; Michaud, Gaëlle; Schubert, Mario; Fan, Yao-Yun; Bucher, Monika; Darbre, Tamis; Aebi, Markus; Reymond, Jean-Louis; Locher, Kaspar P. (2013). Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation. Nature communications, 4(2627), p. 2627. Nature Publishing Group 10.1038/ncomms3627

Reymond, Jean-Louis; Darbre, Tamis (2013). Expanding the Topological Space of Bioactive Peptides. CHIMIA, 67(12), pp. 864-867. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2013.864

Darbre, Tamis; Reymond, Jean-Louis (2012). Dendritic glycopeptides as Pseudomonas aeruginosa biofilm inhibitors. Journal of Peptide Science, 18, S55-S56. Chichester: John Wiley & Sons

Eggimann, G.; Buschor, S.; Darbre, Tamis; Reymond, Jean-Louis (2012). Branched and Dendritic Cell Penetrating Peptides. Journal of Peptide Science, 18, S152-S152. Chichester: John Wiley & Sons

Reymond, Jean-Louis; Darbre, Tamis (2012). Peptide and glycopeptide dendrimer apple trees as enzyme models and for biomedical applications. Organic & biomolecular chemistry, 10(8), pp. 1483-1492. Cambridge: Royal Society of Chemistry 10.1039/c2ob06938e

Stach, Michaela; Maillard, Noélie; Kadam, Rameshwar; Kalbermatter, David; Meury, M.; Page, Malcolm; Fotiadis, Dimitrios José; Darbre, Tamis; Reymond, Jean-Louis (2012). Membrane disrupting antimicrobial peptide dendrimers with multiple amino termini. Medicinal chemistry communications - MedChemComm, 3(1), pp. 86-89. Cambridge: Royal Society of Chemistry 10.1039/c1md00272d

Awale, Mahendra; Reymond, Jean-Louis (2012). Cluster analysis of the DrugBank chemical space using molecular quantum numbers. Bioorganic & medicinal chemistry, 20(18), pp. 5372-5378. Amsterdam: Elsevier 10.1016/j.bmc.2012.03.017

Bréthous, Lise; Garcia-Delgado, Noemi; Schwartz, Julian; Bertrand, Sonia; Bertrand, Daniel; Reymond, Jean-Louis (2012). Synthesis and Nicotinic Receptor Activity of Chemical Space Analogues of N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-Diazabicyclo[3.2.2]nonane-4-carboxylic Acid 4-Bromophenyl Ester (SSR180711). Journal of medicinal chemistry, 55(10), pp. 4605-4618. Easton, Pa.: American Chemical Society 10.1021/jm300030r

Reymond, Jean-Louis; Awale, Mahendra (2012). Exploring Chemical Space for Drug Discovery Using the Chemical Universe Database. ACS chemical neuroscience, 3(9), pp. 649-657. Washington, D.C.: American Chemical Society 10.1021/cn3000422

Reymond, Jean-Louis; Ruddigkeit, Lars; Blum, Lorenz; van Deursen, Ruud (2012). The enumeration of chemical space. Wiley interdisciplinary reviews WIREs - computational molecular science, 2(5), pp. 717-733. Hoboken, N.J.: Wiley-Blackwell 10.1002/wcms.1104

Ruddigkeit, Lars; van Deursen, Ruud; C.Blum, Lorenz; Reymond, Jean-Louis (2012). Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17. Journal of chemical information and modeling, 52(11), pp. 2864-2875. Washington, D.C.: American Chemical Society 10.1021/ci300415d

Bartoloni, Marco; Kadam, Rameshwar U.; Schwartz, Julian; Furrer, Julien; Darbre, Tamis; Reymond, Jean-Louis (2011). Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides. Chemical communications, 47(47), p. 12634. Cambridge: Royal Society of Chemistry 10.1039/c1cc15704c

Kadam, Rameshwar U.; Bergman, Manfred Max; Hurley, Matthew; Garg, Divita; Cacciarini, Martina; Swiderska, Magdalena A.; Nativi, Cristina; Sattler, Michael; Smyth, Alan R.; Williams, Paul; Camara, Miguel; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2011). A Glycopeptide Dendrimer Inhibitor of the Galactose-Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms. Angewandte Chemie (International ed.), 50(45), pp. 10631-10635. Weinheim: Wiley-VCH 10.1002/anie.201104342

Johansson, Emma M.V.; Kadam, Rameshwar U.; Rispoli, Gabriele; Crusz, Shanika A.; Bartels, Kai-Malte; Diggle, Stephen P.; Camara, Miguel; Williams, Paul; Jaeger, Karl-Erich; Darbre, Tamis; Reymond, Jean-Louis (2011). Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids. Medicinal chemistry communications - MedChemComm, 2(5), pp. 418-420. Cambridge: Royal Society of Chemistry 10.1039/c0md00270d

Blum, Lorenz C.; van Deursen, Ruud; Bertrand, Sonia; Mayer, Milena; Buergi, Justus J.; Bertrand, Daniel; Reymond, Jean-Louis (2011). Discovery of alpha 7-Nicotinic Receptor Ligands by Virtual Screening of the Chemical Universe Database GDB-13. Journal of chemical information and modeling, 51(12), pp. 3105-3112. Washington, D.C.: American Chemical Society 10.1021/ci200410u

Blum, Lorenz C.; van Deursen, Ruud; Reymond, Jean-Louis (2011). Visualisation and subsets of the chemical universe database GDB-13 for virtual screening. Journal of computer-aided molecular design, 25(7), pp. 637-647. Dordrecht: Springer Netherlands 10.1007/s10822-011-9436-y

Botelho, Tiago O.; Guevara, Tibisay; Marrero, Aniebrys; Arede, Pedro; Fluxa, Viviana S.; Reymond, Jean-Louis; Oliveira, Duarte C.; Xavier Gomis-Rueth, F. (2011). Structural and Functional Analyses Reveal That Staphylococcus aureus Antibiotic Resistance Factor HmrA Is a Zinc-dependent Endopeptidase. Journal of biological chemistry, 286(29), pp. 25697-25709. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M111.247437

Euzen, Ronan; Reymond, Jean-Louis (2011). Glycopeptide dendrimers: tuning carbohydrate-lectin interactions with amino acids. Molecular bioSystems, 7(2), pp. 411-421. Cambridge: Royal Society of Chemistry 10.1039/c0mb00177e

Euzen, Ronan; Reymond, Jean-Louis (2011). Synthesis of glycopeptide dendrimers, dimerization and affinity for Concanavalin A. Bioorganic & medicinal chemistry, 19(9), pp. 2879-2887. Amsterdam: Elsevier 10.1016/j.bmc.2011.03.047

Fluxa, Viviana S.; Maillard, Noelie; Page, Malcolm G.P.; Reymond, Jean-Louis (2011). Bead diffusion assay for discovering antimicrobial cyclic peptides. Chemical communications, 47(5), pp. 1434-1436. Cambridge: Royal Society of Chemistry 10.1039/c0cc04670a

Maillard, Noelie; Babiak, Peter; Syed, Salahuddin; Biswas, Rasomoy; Mandrich, Luigi; Manco, Giuseppe; Reymond, Jean-Louis (2011). Five-Substrate Cocktail as a Sensor Array for Measuring Enzyme Activity Fingerprints of Lipases and Esterases. Analytical chemistry, 83(4), pp. 1437-1442. Washington, D.C.: American Chemical Society 10.1021/ac102994n

Reymond, Jean-Louis; van Deursen, Ruud; Bertrand, D. (2011). What we have learned from crystal structures of proteins to receptor function. Biochemical pharmacology, 82(11), pp. 1521-1527. New York, N.Y.: Elsevier 10.1016/j.bcp.2011.07.061

Reymond, Jean-Louis; Blum, Lorenz C.; van Deursen, Ruud (2011). Exploring the Chemical Space of Known and Unknown Organic Small Molecules at www.gdb.unibe.ch. CHIMIA, 65(11), pp. 863-867. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2011.863

van Deursen, Ruud; Blum, Lorenz C.; Reymond, Jean-Louis (2011). Visualisation of the chemical space of fragments, lead-like and drug-like molecules in PubChem. Journal of computer-aided molecular design, 25(7), pp. 649-662. Dordrecht: Springer Netherlands 10.1007/s10822-011-9437-x

Maillard, N.; Biswas, Rasomoy; Darbre, Tamis; Reymond, Jean-Louis (2011). Combinatorial Discovery of Peptide Dendrimer Enzyme Models Hydrolyzing Isobutyryl Fluorescein. ACS combinatorial science, 13(3), pp. 310-320. Washington, D.C.: American Chemical Society 10.1021/co200006z

Uhlich, N.A.; Darbre, Tamis; Reymond, Jean-Louis (2011). Peptide dendrimer enzyme models for ester hydrolysis and aldolizationprepared by convergent thioether ligation. Organic & biomolecular chemistry, 9(20), pp. 7071-7084. Cambridge: Royal Society of Chemistry 10.1039/c1ob05877k

Luethi, Erika; Nguyen, Kong T; Bürzle, Marc; Blum, Lorenz C; Suzuki, Yoshiro; Hediger, Matthias; Reymond, Jean-Louis (2010). Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB). Journal of medicinal chemistry, 53(19), pp. 7236-50. Easton, Pa.: American Chemical Society 10.1021/jm100959g

Johansson, Emma M.V.; Dubois, Joëlle; Darbre, Tamis; Reymond, Jean-Louis (2010). Glycopeptide dendrimer colchicine conjugates targeting cancer cells. Bioorganic & medicinal chemistry, 18(17), pp. 6589-6597. Amsterdam: Elsevier 10.1016/j.bmc.2010.04.026

Uhlich, Nicolas A.; Natalello, Antonino; Kadam, Rameshwar U.; Doglia, Silvia M.; Reymond, Jean-Louis; Darbre, Tamis (2010). Structure and Binding of Peptide-Dendrimer Ligands to Vitamin B12. ChemBioChem, 11(3), pp. 358-365. Weinheim: Wiley-VCH 10.1002/cbic.200900657

van Dursen, Ruud; Blum, Lorenz C.; Reymond, Jean-Louis (2010). A Searchable Map of Pubchem. Journal of chemical information and modeling, 50(11), pp. 1924-1934. Washington, D.C.: American Chemical Society 10.1021/ci100237q

Biswas, Rasomoy; Maillard, Noélie; Kofoed, Jacob; Reymond, Jean-Louis (2010). Comparing dendritic with linear esterase peptides by screening SPOT arrays for catalysis. Chemical communications, 46(46), p. 8746. Cambridge: Royal Society of Chemistry 10.1039/c0cc02700f

Garcia-Delgado, Noemi; Bertrand, Sonia; Nguyen, Kong T.; van Deursen, Ruud; Bertrand, Daniel; Reymond, Jean-Louis (2010). Exploring a7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB. ACS medicinal chemistry letters, 1(8), pp. 422-426. Washington, D.C.: American Chemical Society 10.1021/ml100125f

Reymond, Jean-Louis (2010). Selected papers from the Biotrans 2009 Conference. Journal of molecular catalysis. B - enzymatic, 65(1-4), pp. 1-2. Amsterdam: Elsevier 10.1016/j.molcatb.2010.05.006

Reymond, Jean-Louis; Sheldon, Roger A. (2010). Future turnovers in enzyme catalysis. Current opinion in chemical biology, 14(2), pp. 113-114. Amsterdam: Elsevier 10.1016/j.cbpa.2010.02.019

Reymond, Jean-Louis; van Deursen, Ruud; Blum, Lorenz C.; Ruddigkeit, Lars (2010). Chemical space as a source for new drugs. Medicinal chemistry communications - MedChemComm, 1(1), p. 30. Cambridge: Royal Society of Chemistry 10.1039/c0md00020e

Uhlich, Nicolas A.; Sommer, Peter; Bühr, Claudia; Schürch, Stefan; Reymond, Jean-Louis; Darbre, Tamis (2009). Remote Control of Bipyridine-Metal Coordination within a Peptide Dendrimer. Chemical communications(41), p. 6237. Cambridge: Royal Society of Chemistry 10.1039/b912291e

Javor, Sacha; Reymond, Jean-Louis (2009). Structure Activity Relationship Studies in Single-Site-Esterase Peptide Dendrimers. Israel journal of chemistry, 49(1), pp. 129-136. Weinheim: Wiley-VCH 10.1560/IJC.49.1.129

Blum, Lorenz C.; Reymond, Jean-Louis (2009). 970 Million Drug-like Small Molecules for Virtual Screening in the Chemical Universe Database GDB-13 (Communication). Journal of the American Chemical Society, 131(25), pp. 8732-8733. Washington, D.C.: American Chemical Society 10.1021/ja902302h

Sommer, Peter; Fluxa, Viviana S.; Darbre, Tamis; Reymond, Jean-Louis (2009). Proteolysis of Peptide Dendrimers. ChemBioChem, 10(9), pp. 1527-1536. Weinheim: Wiley-VCH 10.1002/cbic.200900060

Dolphin, Gunnar T.; Renaudet, Olivier; Ouberai, Myriam; Dumy, Pascal; Garcia, Julian; Reymond, Jean-Louis (2009). Phenolic oxime oligomers inhibit Alzheimer's amyloid fibril formation and disaggregate fibrils in vitro. ChemBioChem, 10(8), pp. 1325-1329. Weinheim: Wiley-VCH 10.1002/cbic.200900044

Maillard, Noélie; Darbre, Tamis; Reymond, Jean-Louis (2009). Identification of Catalytic Peptide Dendrimers by "Off-Bead" in Silica High-Throughput Screening of Combinatorial Libraries. Journal of combinatorial chemistry, 11(4), pp. 667-675. Washington, D.C.: American Chemical Society 10.1021/cc9000289

Nguyen, Kong Thong; Luethi, Erika; Syed, Salahuddin; Urwyler, Stephan; Bertrand, Sonia; Berrand, Daniel; Reymond, Jean-Louis (2009). 3-(Aminomethyl)piperazine-2,5-dione as a novel NMDA glycine site inhibitor from the chemical universe database GDB. Bioorganic and medicinal chemistry letters, 19(14), pp. 3832-3835. New York, N.Y.: Pergamon 10.1016/j.bmcl.2009.04.021

Javor, Sacha; Reymond, Jean-Louis (2009). Molecular dynamics and docking studies of single site esterase peptide dendrimers. Journal of organic chemistry, 74(10), pp. 3665-3674. Washington, D.C.: American Chemical Society 10.1021/jo802743c

Reymond, Jean-Louis; Nguyen, Kong Thong (2009). Exploration of Chemical Space for Drug Discovery by Database Generation. Chimica oggi / Chemistry today, 27(2), pp. 37-40. Milano: TeknoScienze

Kolomiets, Elena; Swiderska, Magdalena A.; Kadam, Rameshwar U.; Johansson, Emma M.V.; Jaeger, Karl-Erich; Darbre, Tamis; Reymond, Jean-Louis (2009). Glycopeptide dendrimers with high affinity for the fucose binding lectin PA-IIL from Pseudomonas aeruginosa. ChemMedChem, 4(4), pp. 562-569. Weinheim: Wiley-VCH 10.1002/cmdc.200800380

Maillard, Noélie; Clouet, Anthony; Darbre, Tamis; Reymond, Jean-Louis (2009). Combinatorial Libraries of Peptide Dendrimers: Design, Synthesis, On-Bead High-Throughput Screening, Bead Decoding and Characterization. Nature protocols, 4(2), pp. 132-142. London: Nature Publishing Group 10.1038/nprot.2008.241

Reymond, Jean-Louis; Fluxa, Viviana S.; Maillard, Noélie (2009). Enzyme Assays. Chemical communications(1), pp. 34-46. Cambridge: Royal Society of Chemistry 10.1039/b813732c

Fluxa, Viviana S.; Reymond, Jean-Louis (2009). On-bed cyclization in a combinatorial library of 15.625 octapeptides. Bioorganic & medicinal chemistry, 17(3), pp. 1018-1025. Amsterdam: Elsevier 10.1016/j.bmc.2008.01.045

Javor, Sacha; Natalello, Antonino; Doglia, Silvia Maria; Reymond, Jean-Louis (2008). a-Helix Stabilization within a Peptide Dendrimer [Communication]. Journal of the American Chemical Society, 130(51), pp. 17248-17249. Washington, D.C.: American Chemical Society 10.1021/ja8076236

Johansson, Emma M.V.; Crusz, Shanika A.; Kolomiets, Elena; Buts, Lieven; Kadam, Rameshwar U.; Cacciarini, Martina; Bartels, Kai-Malte; Diggle, Stephen P.; Cámara, Miguel; Williams, Paul; Loris, Remy; Nativi, Cristina; Rosenau, Frank; Jaeger, Karl-Erich; Darbre, Tamis; Reymond, Jean-Louis (2008). Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB. Chemistry & biology, 15(12), pp. 1249-1257. San Francisco, Calif.: Current Biology Ltd. 10.1016/j.chembiol.2008.10.009

Duléry, Vincent; Uhlich, Nicolas A.; Maillard, Noélie; Fluxa, Viviana S.; Garcia, Julian; Dumy, Pascal; Renaudet, Olivier; Reymond, Jean-Louis; Darbre, Tamis (2008). A cyclodecapeptide ligand to vitamin B12. Organic & biomolecular chemistry, 6(22), pp. 4134-4141. Cambridge: Royal Society of Chemistry 10.1039/b811234g

Darbre, Tamis; Reymond, Jean-Louis (2008). Glycopeptide dendrimers for biomedical applications. Current topics in medicinal chemistry, 8(14), pp. 1286-1293. Hilversum: Bentham Science Publishers 10.2174/156802608785849058

Nguyen, Kong Thong; Syed, Salahuddin; Urwyler, Stephan; Bertrand, Sonia; Bertrand, Daniel; Reymond, Jean-Louis (2008). Discovery of NMDA Glycine Site Inhibitors from the Chemical Universe Database GDB. ChemMedChem, 3(10), pp. 1520-1524. Weinheim: Wiley-VCH 10.1002/cmdc.200800198

Fluxa, Viviana S.; Wahler, Denis; Reymond, Jean-Louis (2008). Enzyme assay and activity fingerprinting of hydrolases with red-chromogenic adrenaline test. Nature protocols, 3(8), pp. 1270-1277. London: Nature Publishing Group 10.1038/nprot.2008.106

Sommer, Peter; Uhlich, Nicolas; Reymond, Jean-Louis; Darbre, Tamis (2008). A Peptide Dendrimer Model for Vitamin B(12). ChemBioChem, 9(5), pp. 689-693. Weinheim: Wiley-VCH 10.1002/cbic.200700606

Reymond, Jean-Louis (2008). Substrate Arrays for Fluorescence-Based Enzyme Fingerpringing and High-Throughput Screening. Annals of the New York Academy of Sciences, 1130(1), pp. 12-20. Boston, Mass.: Blackwell 10.1196/annals.1430.000

Swiderska, Magdalena; Reymond, Jean-Louis (2008). A dendritic signal amplifier (commentary). Nature chemistry, 1(7), pp. 527-528. London: Nature Publishing Group 10.1038/nchem.385

Nguyen, Kong Thong; Blum, Lorenz C.; van Deursen, Ruud; Reymond, Jean-Louis (2008). Classification of Organic Molecules by Molecular Quantum Numbers (Communication). ChemMedChem, 4(11), pp. 1803-1805. Weinheim: Wiley-VCH 10.1002/cmdc.200900317

Kofoed, Jacob; Reymond, Jean-Louis (2007). Identification of protease substrates by combinatorial profiling on tentagel bead. Chemical communications, 43, pp. 4453-4455. Cambridge: Royal Society of Chemistry 10.1039/b713595e

Kofoed, Jacob; Reymond, Jean-Louis (2007). A General Method for Designing Combinatorial Peptide Libraries Decodable by Amino Acid Analysis. Journal of combinatorial chemistry, 9(6), pp. 1046-1052. Washington, D.C.: American Chemical Society 10.1021/cc7001155

Javor, Sacha; Delort, Estelle; Darbre, Tamis; Reymond, Jean-Louis (2007). A Peptide Dendrimer Enzyme Model with a Single Catalytic Site at the Core. Journal of the American Chemical Society, 129(43), pp. 13238-13246. Washington, D.C.: American Chemical Society 10.1021/ja074115f

Delort, Estelle; Szöcs, Edit; Widmer, Roland; Siegenthaler, Hans; Reymond, Jean-Louis (2007). STM-Visualization of Thiol-Containing Peptide Dendrimers on Au(111). Macromolecular bioscience, 7(8), pp. 1024-1031. Weinheim: Wiley-VCH 10.1002/mabi.200700036

Johansson, Emma; Kolomiets, Elena; Rosenau, Frank; Jaeger, Karl-Erich; Darbre, Tamis; Reymond, Jean-Louis (2007). Combinatorial Variation of Branching Length and Multivalency in a Large (390,625 Member) Glycopeptide Dendrimer Library: Ligands for Fucose-specific Lectins. New journal of chemistry, 31(7), pp. 1291-1299. London: Royal Society of Chemistry 10.1039/b616051b

Kolomiets, Elena; Johansson, Emma; Renaudet, Olivier; Darbre, Tamis; Reymond, Jean-Louis (2007). Neoglycopeptide Dendrimer Libraries as a Source of Lectin Binding Ligands. Organic letters, 9(8), pp. 1465-1468. Washington, D.C.: American Chemical Society 10.1021/ol070119d

van Deursen, Ruud; Reymond, Jean-Louis (2007). Chemical Space Travel. ChemMedChem, 2(5), pp. 636-640. Weinheim: Wiley-VCH 10.1002/cmdc.200700021

Fink, Tobias; Reymond, Jean-Louis (2007). Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physico-chemical properties, compound classes and drug discovery. Journal of chemical information and modeling, 47(2), pp. 342-353. Washington, D.C.: American Chemical Society 10.1021/ci600423u

Sicart, Renaud; Collin, Marie-Pierre; Reymond, Jean-Louis (2007). Fluorogenic Substrates for Lipases, Esterases and Acylases Using a TIM-Mechanism for Signal Release. Biotechnology journal, 2(2), pp. 221-231. Weinheim: Wiley 10.1002/biot.200600181

Darbre, Tamis; Reymond, Jean-Louis (2007). A Peptide Dendrimer Approach to Artificial Enzymes. Chimica oggi / Chemistry today, 25, pp. 25-27. Milano: TeknoScienze

Tallant, Cynthia; García-Castellanos, Raquel; Marrero, Aniebrys; Canals, Francesc; Yang, Yongzheng; Reymond, Jean-Louis; Solà, Maria; Baumann, Ulrich; Gomis-Rüth, F. Xavier (2007). Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP proteas. Biological chemistry, 388(1), pp. 1243-1253. Berlin: Walter de Gruyter 10.1515/BC.2007.143

Darbre, Tamis; Reymond, Jean-Louis (2006). Peptide Dendrimers as Artificial Enzymes, Receptors, and Drug-Delivery Agents. Accounts of chemical research, 39(12), pp. 925-934. Easton, Pa.: American Chemical Society 10.1021/ar050203y

Kofoed, Jacob; Darbre, Tamis; Reymond, Jean-Louis (2006). Artificial aldolases from peptide dendrimer combinatorial libraries. Organic & biomolecular chemistry, 4(17), pp. 3268-3281. Cambridge: Royal Society of Chemistry 10.1039/b607342e

Grognux, Johann; Reymond, Jean-Louis (2006). A red-fluorescent substrate microarray for lipase fingerprinting. Molecular bioSystems, 2(10), pp. 492-498. Cambridge: Royal Society of Chemistry 10.1039/b609275f

Delort, Estelle; Nguyen-Trung, Nhat-Quang; Darbre, Tamis; Reymond, Jean-Louis (2006). Synthesis and Activity of Histidine Containing Catalytic Peptide Dendrimers. Journal of organic chemistry, 71(12), pp. 4468-4480. Washington, D.C.: American Chemical Society 10.1021/jo060273y

Elend, C; Schmeisser, C; Leggewie, C; Babiak, Peter; Carballeira, José Daniel; Steele, H; Reymond, Jean-Louis; Jaeger, Karl-Erich; Streit, Wolfgang (2006). Isolation and biochemical characterization of two novel metagenome-derived esterases. Applied and environmental microbiology, 72(5), pp. 3637-3645. Washington, D.C.: American Society for Microbiology 10.1128/AEM.72.5.3637-3645.2006

Yang, Yongzheng; Babiak, Peter; Reymond, Jean-Louis (2006). Low background FRET- substrates for lipases and esterases suitable for high-throughput screening under basic (pH 11) conditions. Organic & biomolecular chemistry, 4(9), pp. 1746-1754. Cambridge: Royal Society of Chemistry 10.1039/b601151a

Kofoed, Jacob; Darbre, Tamis; Reymond, Jean-Louis (2006). Dual Mechanism of Zinc-Proline Catalyzed Aldol Reactions in Water. Chemical communications, 14(14), p. 1482. Cambridge: Royal Society of Chemistry 10.1039/b600703a

Yang, Yongzheng; Babiak, Peter; Reymond, Jean-Louis (2006). New Monofunctionalized Fluorescein Derivatives for the Efficient High-Throughput Screening of Lipases and Esterases in Aqueous Media. Helvetica chimica acta, 89(3), pp. 404-415. Basel: Verlag Helvetica Chimica Acta 10.1002/hlca.200690041

Clouet, Anthony; Darbre, Tamis; Reymond, Jean-Louis (2006). Combinatorial Synthesis, Selection and Properties of Esterase Peptide Dendrimers. Biopolymers, 84(1), pp. 114-123. Hoboken, N.J.: John Wiley & Sons, Inc. 10.1002/bip.20394

Zheng, Lei; Baumann, Ulrich; Reymond, Jean-Louis (2004). An efficient one-step site-directed and site-saturation mutagenesis protocol. Nucleic acids research, 32(14), e115-e115. Oxford University Press 10.1093/nar/gnh110

Zheng, Lei; Baumann, Ulrich; Reymond, Jean-Louis (2003). Production of a Functional Catalytic Antibody ScFv-NusA Fusion Protein in Bacterial Cytoplasm. Journal of Biochemistry, 133(5), pp. 577-581. Japanese Biochemical Society 10.1093/jb/mvg074

Newspaper or Magazine Article

Reymond, Jean-Louis (21 December 2022). Molecular Similarity for Drug Discovery, Target Prediction and Chemical Space Visualization. CHIMIA, 76(12), pp. 1045-1051. Swiss Chemical Society 10.2533/chimia.2022.1045

Ho, Manh Tin; Berger, Stephan; Müller, Philipp; Simonin, Céline; Reymond, Jean-Louis; von Ballmoos, Christoph; Fuster, Daniel G. (21 December 2022). Physiological and Molecular Function of the Sodium/Hydrogen Exchanger NHA2 (SLC9B2). CHIMIA, 76(12), pp. 1019-1024. Swiss Chemical Society 10.2533/chimia.2022.1019

Rossetti, Valentina; Reymond, Jean-Louis (21 December 2022). Vitaport: A Learning and Artistic Path for Public Outreach on Transporter Biology, Health and Drug Discovery. CHIMIA, 76(12), pp. 1063-1067. Swiss Chemical Society 10.2533/chimia.2022.1063

Thakkar, Amol; Reymond, Jean-Louis (27 April 2022). Automatic Extraction of Reaction Templates for Synthesis Prediction. CHIMIA, 76(4), p. 294. Swiss Chemical Society 10.2533/chimia.2022.294

Patrulea, Viorica; Gan, Bee-Ha; Perron, Karl; Cai, Xingguang; Abdel-Sayed, Philippe; Sublet, Emmanuelle; Ducret, Verena; Nerhot, Natalia Porroche; Applegate, Lee Ann; Borchard, Gerrit; Reymond, Jean-Louis; Jordan, Olivier (15 March 2022). Synergistic effects of antimicrobial peptide dendrimer-chitosan polymer conjugates against Pseudomonas aeruginosa. Carbohydrate polymers, 280, p. 119025. Elsevier 10.1016/j.carbpol.2021.119025

Neier, Reinhard; Reymond, Jean-Louis (2014). A Tribute to Pierre Vogel. Arkivoc, 2014(3), pp. 1-5. Michigan Publishing 10.3998/ark.5550190.0015.301

Book Section

Awale, Mahendra; Reymond, Jean-Louis (2019). Web-Based Tools for Polypharmacology Prediction. In: Ziegler, Slava; Waldmann, Herbert (eds.) Systems Chemical Biology. Methods in molecular biology: Vol. 1888 (pp. 255-272). Humana Press 10.1007/978-1-4939-8891-4_15

Reymond, Jean-Louis; Visini, Ricardo; Awale, Mahendra (2016). Enumeration of Chemical Fragment Space. In: Erlanson, Daniel A.; Jahnke, Wolfgang (eds.) Fragment-based Drug Discovery Lessons and Outlook. Methods and Principles in Medicinal Chemistry (pp. 57-74). Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA 10.1002/9783527683604.ch03

Ruddigkeit, Lars; Reymond, Jean-Louis (2014). The Chemical Space of Flavours. In: Martinez-Mayorga, Karina; Medina-Franco, José Luis (eds.) Foodinformatics - Applications of Chemical Information to Food Chemistry (pp. 83-96). Heidelberg, Germany: Springer 10.1007/978-3-319-10226-9_2

Reymond, Jean-Louis; Ruddigkeit, Lars; Awale, Mahendra (2014). Considerations on the Drug-Like Chemical Space. In: Jacoby, Edgar (ed.) Computational Chemogenomics (pp. 39-64). Singapore: Pan Stanford Publishing

Reymond, Jean-Louis (2012). Screening Methods for Enzymes. In: Carreira, Eric M.; Yamamoto, Hisashi (eds.) Comprehensive Chirality. Volume 7: Synthetic Methods VI - Enzymatic and Semi-Enzymatic (pp. 6-20). Amsterdam: Elsevier 10.1016/B978-0-08-095167-6.00702-3

Reymond, Jean-Louis; Darbre, Tamis (2011). Combinatorial Libraries of Dendritic Glycoclusters. In: Renaudet, O.; Spinelli, N. (eds.) Synthesis and Biological Applications of Glycoconjugates (pp. 116-128). Bentham Science Publishers

Darbre, T.; Reymond, Jean-Louis (2011). Peptide Dendrimers as Artificial Proteins. In: Campagna, S.; Ceroni, P.; Puntoriero, F. (eds.) Designing Dendrimers (pp. 505-528). Chichester: John Wiley & Sons

Reymond, Jean-Louis (2008). Colorimetric and Fluorescence-Based Screening. In: Lutz, Stefan; Bornscheuner, Uwe Theo (eds.) Protein Engineering Handbook (pp. 669-711). Weinheim: Wiley-VCH

Reymond, Jean-Louis; Streit, W. (2008). The Search for New Enzymes. In: Gotor, Vincente; Alfonso, Ignacio; Garcia-Uridales, Eduardo (eds.) Asymmetric Organic Synthesis with Enzymes (pp. 65-86). Weinheim: Wiley-VCH

Reymond, Jean-Louis (2008). Fluorescence Assays for Biotransformations. In: Fessner, Wolf-Dieter; Anthonsen, Thorleif (eds.) Modern Biocatalysis (pp. 1-16). Weinheim: Wiley-VCH

Reymond, Jean-Louis; Babiak, Peter (2007). Screening Systems. In: Ulber, Roland; Sell, Dieter (eds.) White Biotechnology. Advances in Biochemical Engineering/Biotechnology: Vol. 105 (pp. 31-58). Heidelberg: Springer Verlag 10.1007/10_2006_032

Reymond, Jean-Louis (2006). Fingerprinting Methods for Hydrolases. In: Reymond, Jean-Louis (ed.) Enzyme Assays: High-throughput Screening, Genetic Selection and Fingerprinting (pp. 271-302). Weinheim: Wiley-VCH

Book

Reymond, Jean-Louis (ed.) (2006). Enzyme Assays: High-throughput Screening, Genetic Selection and Fingerprinting 15. Weinheim: Wiley-VCH 10.1016/j.copbio.2004.06.008

Conference or Workshop Item

Personne, Hippolyte Jean-Claude René; Baeriswyl, Stéphane; Stocker, Achim; Javor, Sacha; Reymond, Jean-Louis (25 August 2020). X-Ray Crystallographic Studies of Short Antimicrobial Helical Peptides against Multidrug Resistant Gram-Negative Bacteria (Unpublished). In: SCS Fall meeting 2020. University of Bern. 25th August 2020.

Zamolo, Susanna Joelle; Reymond, Jean-Louis; Darbre, Tamis (22 June 2019). Peptide based vectors for CRISPR-Cas9 delivery (Unpublished). In: 26th American Peptide Symposium. Monterey, CA. 22-27 June 2019.

Borgström, A.; Kiener, M.; Kappel, S.; Hauert, B.; Delalande, C.; Zoni, E.; Reymond, J.; Thalmann, G. N.; Peinelt, C.; Kruithof-de Julio, M. (15 March 2019). Investigation of TRPM4 and store-operated calcium entry in prostate cancer cell systems and a primary prostate cancer stem cell model. European Urology Supplements, 18(1), e342-e342. Elsevier https://doi.org/10.1016/S1569-9056(19)30254-4

Capecchi, Alice; Reymond, Jean-Louis (2019). Peptide chemical space (Unpublished). In: SCS fall meeting 2019.

Zamolo, Susanna Joelle; Reymond, Jean-Louis (7 September 2018). Peptide dendrimes as delivery systems for nucleic acids (Unpublished). In: Swiss Chemical Society - Fall meeting, (Lausanne, Switzerland). Lausanne, Switzerland. 7 Sept.2018.

Zamolo, Susanna Joelle; Reymond, Jean-Louis (August 2018). Peptide dendrimes as delivery systems for nucleic acids (Unpublished). In: Swiss Summer School in Chemical Biology (Villars-sur-Ollon, Switzerland. Villars-sur-Ollon, Switzerland. 19-23 Aug.2018.

Zamolo, Susanna Joelle; Reymond, Jean-Louis (August 2018). Peptide dendrimes as delivery systems for nucleic acids (Unpublished). In: Swiss Summer School in Chemical Biology (Villars-sur-Ollon, Switzerland). Villars-sur-Ollon, Switzerland. 19-23 Aug.2018.

Zamolo, Susanna Joelle; Reymond, Jean-Louis (June 2018). Peptide dendrimes as delivery systems for nucleic acids (Unpublished). In: Summer School (5 days) Nucleic Acids in Therapy (Stockholm, Sweden). Stockholm. 25-30 Jun.2018.

Capecchi, Alice; Awale, Mahendra; Probst, Daniel; Reymond, Jean-Louis (2018). Beyond Lipinski – an analysis of the PubChem chemical space (Unpublished). In: Summer School on Machine Learning in Drug Design. Leuven, Belgium. Monday, August 20, 2018 - to Wednesday, August 22, 2018.

He, Runze; Reymond, Jean-Louis (2015). Activity and structure studies of antimicrobial cyclic peptides with L,D- architecture linked by a phenyl group (Unpublished). In: SCG Fall Meeting 2015. EPFL Lausanne. 2015.

He, Runze; Reymond, Jean-Louis (11 September 2014). Synergistic folding and potency increase in an antimicrobial peptide pair against Pseudomonas aeruginosa (Unpublished). In: 2014 SCG fall Meeting. Universität Zürich. 11.09.2014.

Michaud, Gaëlle; Bergman, Manfred Max; Salerno, Gianluca; Gillon, Emilie; Imberty, Anne; Richichi, Barbara; Nativi, Cristina; Darbre, Tamis; Reymond, Jean-Louis (June 2014). Synthesis of glycopeptide dendrimers targeting LecA, LecB, or both (Unpublished). In: COST MultiGlycoNano Meeting. Siena, Italy. 25.-28.06.2014.

Lüscher, Benjamin; Clemençon, Benjamin; Marini, Camilla; Huang, Xiao; Sager, Ruth; Jeanneret, Céline; Reymond, Jean-Louis; Albrecht, Christiane; Hediger, Matthias; Surbek, Daniel; Baumann, Marc Ulrich (January 2014). Placental Uric Acid Transport System: Glucose Transporter 9 (SLC2A9). Reproductive sciences, 21(3), 303A-303A. Sage

Jeanneret, Céline; Reymond, Jean-Louis (2014). Discovery of TRPV6 inhibitors using ligand based virtual screening (Unpublished). In: International Symposium on Medicinal Chemistry. Lisbon, Portugal. 07.-11.09.2014.

Simonin, Céline; Reymond, Jean-Louis (2014). Discovery of TRPV6 Inhibitors Using Ligand Based Virtual Screening (Unpublished). In: Swiss-Japanese Symposium in Chemical Biology. Berne. 02-03.10.2014.

Bartoloni, M.; Darbre, Tamis; Reymond, Jean-Louis (2012). Synthesis and structure determination of bicyclic bridged peptides. Journal of Peptide Science, 18(S1), S170-S170. John Wiley & Sons

Blattes, E.; Bartoloni, M.; Darbre, Tamis; Reymond, Jean-Louis (2012). Biological applications of bicyclic peptides. Journal of Peptide Science, 18(Supplement), S93-S93. John Wiley & Sons 10.1002/psc.2449

Stach, M.; Darbre, Tamis; Reymond, Jean-Louis (2012). Membrane disrupting antimicrobial peptide dendrimers with multiple amino termini. Journal of Peptide Science, 18, S63-S64. John Wiley & Sons

Jeanneret, C.; Reymond, Jean-Louis (2012). Discovery of NHA2 Inhibitors Using Ligand Based Virtual Screening. In: NCCR TransCure Site Visit. Bern. 15.-16.10.2012.

Jeanneret, C.; Reymond, J.-L. (2012). Ligand Based Discovery of TRPV6 Inhibitors. In: NCCR TransCure Site Visit. Bern. 15.-16.10.2012.

Jeanneret, C.; Reymond, Jean-Louis (2012). Development of New TRPV6 Inhibitors. In: Präsentation anlässlich des NCCR TransCure Annual Retreat. Gruyère. 30.05.-01.06.2012.

Reymond, Jean-Louis (2009). Exploration of Chemical Space for Drug Discovery by Database Generation. ABC Technologies Meeting, Basel, January 22, 2009.

Reymond, Jean-Louis (2009). Chemical Space Dimensions. COST Angiokem WG Meeting, Prague, April 3, 2009.

Reymond, Jean-Louis (2009). Glycopeptide Dendrimers and RAFTs as Antibacterial Agents. COST D34 Meeting, Edinburgh, May 8, 2009.

Reymond, Jean-Louis (2009). What is contained in Chemical Space? Gordon Conference on CADD, Tilton School, NH, July 22, 2009.

Reymond, Jean-Louis (2009). Exploration of Chemical Space for Drug Discovery by Database Generation. Swiss-Japanese Biomolecular Chemistry Symposium, September 11-12, 2009.

Reymond, Jean-Louis (2009). The Cemical Universe Database GDB and its Use for Drug Discovery. Max Planck Institut, Dortmund, September 16, 2009.

Reymond, Jean-Louis (2009). Exploration of Chemical Space for Drug Discovery by Database Generation. Nature Chemical Biology Symposium, Boston, September 20, 2009.

Reymond, Jean-Louis (2009). Substrate Arrays for Fluorescence-Based Enzyme Fingerprinting and High-Throughput Screening. Biotecnet, Olten, November 18, 2009.

Reymond, Jean-Louis (2009). Sprachliche Generierung neuer Moleküle. Collegium Generale, Universität Bern, November 18, 2009.

Reymond, Jean-Louis (2009). Exploration of Chemical Space for Drug Discovery by Database Generation. Glaxo-Smithkline, London, December 3, 2009.

Reymond, Jean-Louis (2009). Exploring Chemical Space with DCB. European Bioinformatics Institute, Cambridge, U.K., December 4, 2009.

Reymond, Jean-Louis (2008). Substrate Arrays for Fluorescence-based Enzyme Fingerprinting and High-Throughput Screening, University of Bicocca, Milano, January 28, 2008.

Reymond, Jean-Louis (2008). Substrate Arrays for Fluorescence-based Enzyme Fingerprinting and High-Throughput Screening, Polytecnica Milano, January 29, 2008.

Reymond, Jean-Louis (2008). A Chemical Information Strategy to Define New Synthetic Targets. COST ACTION ANGIOKEM, CM0602. Workshop of working groups 3 and 4. Certosa di Pontignano, Siena, February 15-16, 2008.

Reymond, Jean-Louis (2008). Artifical Proteins and Glycoproteins with Peptide Dendrimers. Société Française de Chimie. Journée commune SFC-DCO/SCT/ANP. Ecole Nationale Supérieure de Chimie de Paris.March 11, 2008.

Reymond, Jean-Louis (2008). Methods for Enzyme High-Throughput Screening and Fingerprinting. Workshop on Directed Evolution. Jülich Forschungszentrum, Jülich. March 12, 2008.

Reymond, Jean-Louis (2008). Metal Coordinating Peptide Dendrimers. IBAAC final meeeting, Ecole de Chimie Paris. March 17-18, 2008.

Reymond, Jean-Louis (2008). Exploration of Chemical Space for Drug Discovery by Database Generation. University of Southern Florida, Tampa, April 3, 2008.

Reymond, Jean-Louis (2008). Exploration of Chemical Space for Drug Discovery by Database Generation. American Chemical Society Meeting Spring 2008, New Orleans, communication no 74 (Thomas Kuhn Paradigm Shift Award Competition). April 7, 2008.

Reymond, Jean-Louis (2008). Exploration of Chemical Space for Drug Discovery by Database Generation. Pfizer Research Center, Groton, CT. April 8, 2008.

Reymond, Jean-Louis (2008). Practical Methods for Enzyme High-Throughput Screening and Fingerprinting. CBSO Bussang, France. June 3, 2008.

Reymond, Jean-Louis (2008). The Search for Artificial Enzymes: from Antibodies to Dendrimers. Trends in Enzymology, St.-Malo, France. July 3, 2008.

Reymond, Jean-Louis (2008). Two Stories of Inhibitors from Libraries: Biofilms and Neurochemicals. Columbia University, New York, July 14, 2008.

Reymond, Jean-Louis (2008). Exploration of Chemical Space for Drug Discovery by Database Generation. EFMS-ISMC Meeting, Vienna. September 3, 2008.

Reymond, Jean-Louis (2008). Exploration of Chemical Space for Drug Discovery by Database Generation. University of New Mexico. November 3, 2008.

Reymond, Jean-Louis (2008). Peptide Dendrimers as Protein Enzymes and Glycoproteins. University of Minnesota. November 11, 2008.

Reymond, Jean-Louis (2008). Exploration of Chemical Space for Drug Discovery by Database Generation. University of California, San Francisco. November 20, 2008.

Reymond, Jean-Louis (2008). Designing screens and screening designs: from catalytic antibodies to peptide dendimer enzyme models. University of Cambridge, UK. December 8, 2008.

Working Paper

Schwaller, Philippe; Probst, Daniel; Vaucher, Alain C.; Nair, Vishnu H; Laino, Teodoro; Reymond, Jean-Louis (26 December 2019). Data-Driven Chemical Reaction Classification, Fingerprinting and Clustering using Attention-Based Neural Networks ChemRxiv 10.26434/chemrxiv.9897365.v2