Departement für Chemie, Biochemie und Pharmazie

Lehre & Forschung

  

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Lebenslauf

  • 1974: Born
  • 1995-2000: Diploma studies in Biochemistry, ETH Zürich (Prof. Josef Brunner)
  • 2001-2005: PhD thesis on ATP synthase at the Institute of Microbiology, ETH Zürich (Prof. Peter Dimroth)
  • 2005-2008: Post-Doc (2005) and Group Leader (2006-2008) at the Institute of Microbiology, ETH Zürich (Prof. Peter Dimroth)
  • 2008-2011: SNF Fellow (3 years) at the Department of Biophysics and Biochemistry, Stockholm University (Prof. Peter Brzezinski)
  • 2012-2014: Principal Investigator (Swedish Research Council, VR) at the Department of Biophysics and Biochemistry, University of Stockholm
  • Since April 2014: Assistant Professor Tenure Track at the Department of Chemistry and Biochemistry / Department of Chemistry, Biochemistry and Pharmaceutical Sciences (since January 2021), University of Bern
  • Since August 2017: "ausserordentlicher Professor" the Department of Chemistry and Biochemistry / Department of Chemistry, Biochemistry and Pharmaceutical Sciences (since January 2021), University of Bern

 

Forschungsschwerpunkt

Molecule and signal transport between cellular compartments is performed by membrane proteins, the doors and windows of biological membranes. The complexity of an intact membrane, however, complicates the analysis of membrane proteins. In our group, we aim to simplify the complexity of natural membranes by reconstituting selected, purified components into a lipid bilayer. Such in vitro systems help to elucidate the molecular details of cellular processes involving membrane proteins.

Major interests:

  • Development of new methods for membrane protein reconstitution
  • The molecular interplay of respiratory enzymes (e.g. cytochrome oxidase, ATP synthase) and the active role of the membrane in proton transport
  • Molecular mechanism of a membrane bound transcription factor involved in antibiotic resistance

 

Publikationen

Jump to: Journal Article | Newspaper or Magazine Article | Book Section | Conference or Workshop Item | Working Paper

Journal Article

Gigon, Lea; Müller, Philipp; Haenni, Beat; Iacovache, Ioan; Barbo, Maruša; Gosheva, Gordana; Yousefi, Shida; Soragni, Alice; von Ballmoos, Christoph; Zuber, Benoît; Simon, Hans-Uwe (2024). Membrane damage by MBP-1 is mediated by pore formation and amplified by mtDNA. Cell reports, 43(4), p. 114084. Cell Press 10.1016/j.celrep.2024.114084

Amati, Andrea Marco; Moning, Stefan Urs; Javor, Sacha; Schär, Sandra; Deutschmann, Sabina; Reymond, Jean-Louis; von Ballmoos, Christoph (2024). Overcoming Protein Orientation Mismatch Enables Efficient Nanoscale Light-Driven ATP Production. ACS synthetic biology, 13(4), pp. 1355-1364. American Chemical Society 10.1021/acssynbio.4c00058

Winkelmann, Iven; Uzdavinys, Povilas; Kenney, Ian M; Brock, Joseph; Meier, Pascal F; Wagner, Lina-Marie; Gabriel, Florian; Jung, Sukkyeong; Matsuoka, Rei; von Ballmoos, Christoph; Beckstein, Oliver; Drew, David (2022). Crystal structure of the Na+/H+ antiporter NhaA at active pH reveals the mechanistic basis for pH sensing. Nature Communications, 13(1), p. 6383. Springer Nature 10.1038/s41467-022-34120-z

Abou Hamdan, Abbas; Mahler, Roman; Grossenbacher, Philipp; Biner, Olivier; Sjöstrand, Dan; Lochner, Martin; Högbom, Martin; von Ballmoos, Christoph (2022). Functional design of bacterial superoxide:quinone oxidoreductase. Biochimica et biophysica acta. Bioenergetics, 1863(7), p. 148583. Elsevier 10.1016/j.bbabio.2022.148583

Dolder, Nicolas; Müller, Philipp; von Ballmoos, Christoph (2022). Experimental platform for the functional investigation of membrane proteins in giant unilamellar vesicles. Soft matter, 18(31), pp. 5877-5893. Royal Society of Chemistry 10.1039/d2sm00551d

Deutschmann, Sabina; Rimle, Lukas; von Ballmoos, Christoph (2022). Rapid Estimation of Membrane Protein Orientation in Liposomes. ChemBioChem, 23(2), e202100543. Wiley-VCH 10.1002/cbic.202100543

Graf, Simone Sandra; Hong, Sangjin; Müller, Philipp; Gennis, Robert; von Ballmoos, Christoph (2021). Energy transfer between the nicotinamide nucleotide transhydrogenase and ATP synthase of Escherichia coli. Scientific reports, 11(1), p. 21234. Springer Nature 10.1038/s41598-021-00651-6

Agne, Michael; Estelmann, Sebastian; Seelmann, Carola S.; Kung, Johannes; Wilkens, Dennis; Koch, Hans-Georg; van der Does, Chris; Albers, Sonja V.; von Ballmoos, Christoph; Simon, Jörg; Boll, Matthias (2021). The missing enzymatic link in syntrophic methane formation from fatty acids. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 118(40), e2111682118. National Academy of Sciences NAS 10.1073/pnas.2111682118

Nuber, Franziska; Schimpf, Johannes; di Rago, Jean-Paul; Tribouillard-Tanvier, Déborah; Procaccio, Vincent; Martin-Negrier, Marie-Laure; Trimouille, Aurélien; Biner, Olivier; von Ballmoos, Christoph; Friedrich, Thorsten (2021). Biochemical consequences of two clinically relevant ND-gene mutations in Escherichia coli respiratory complex I. Scientific reports, 11(1), p. 12641. Springer Nature 10.1038/s41598-021-91631-3

Amati, Andrea Marco; Graf, Simone; Deutschmann, Sabina; Dolder, Nicolas; von Ballmoos, Christoph (2020). Current problems and future avenues in proteoliposome research. Biochemical Society transactions, 48(4), pp. 1473-1492. Portland Press 10.1042/BST20190966

Dolder, Nicolas; von Ballmoos, Christoph (2020). Bifunctional DNA Duplexes Permit Efficient Incorporation of pH Probes into Liposomes. ChemBioChem, 21(15), pp. 2219-2224. Wiley-VCH 10.1002/cbic.202000146

Bruggisser, Julia; Tarek, Basma; Wyder, Marianne; Müller, Philipp; von Ballmoos, Christoph; Witz, Guillaume; Enzmann, Gaby; Deutsch, Urban; Engelhardt, Britta; Posthaus, Horst (2020). CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin. Cell host & microbe, 28(1), pp. 69-78. Cell Press 10.1016/j.chom.2020.05.003

Toth, Alexandra; Meyrat, Axel; Stoldt, Stefan; Santiago, Ricardo; Wenzel, Dirk; Jakobs, Stefan; von Ballmoos, Christoph; Ott, Martin (2020). Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranes. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 117(5), pp. 2412-2421. National Academy of Sciences NAS 10.1073/pnas.1917968117

Graf, Simone; Brzezinski, Peter; von Ballmoos, Christoph (2019). The proton pumping bo oxidase from Vitreoscilla. Scientific reports, 9(1), p. 4766. Springer Nature 10.1038/s41598-019-40723-2

Meyrat, Axel; von Ballmoos, Christoph (2019). ATP synthesis at physiological nucleotide concentrations. Scientific reports, 9(1), p. 3070. Springer Nature 10.1038/s41598-019-38564-0

Lundgren, Camilla A K; Sjöstrand, Dan; Biner, Olivier; Bennett, Matthew; Rudling, Axel; Johansson, Ann-Louise; Brzezinski, Peter; Carlsson, Jens; von Ballmoos, Christoph; Högbom, Martin (2018). Scavenging of superoxide by a membrane-bound superoxide oxidase. Nature chemical biology, 14(8), pp. 788-793. Springer Nature 10.1038/s41589-018-0072-x

Biner, Olivier Felix; Schick, Thomas; Ganguin, Aymar Abel; von Ballmoos, Christoph (2018). Towards a Synthetic Mitochondrion. CHIMIA, 72(5), pp. 291-296. Schweizerische Chemische Gesellschaft 10.2533/chimia.2018.291

Belevich, Nikolai; von Ballmoos, Christoph; Verkhovskaya, Marina (2017). Activation of Proton Translocation by Respiratory Complex I. Biochemistry, 56(42), pp. 5691-5697. American Chemical Society 10.1021/acs.biochem.7b00727

Sjöholm, Johannes; Bergstrand, Jan; Nilsson, Tobias; Šachl, Radek; von Ballmoos, Christoph; Widengren, Jerker; Brzezinski, Peter (2017). The lateral distance between a proton pump and ATP synthase determines the ATP-synthesis rate. Scientific Reports, 7(1), p. 2926. Nature Publishing Group 10.1038/s41598-017-02836-4

Poiana, Federica; von Ballmoos, Christoph; Gonska, Nathalie; Blomberg, Margareta R. A.; Ädelroth, Pia; Brzezinski, Peter (2017). Splitting of the O–O bond at the heme-copper catalytic site of respiratory oxidases. Science Advances, 3(6), e1700279. American Association for the Advancement of Science 10.1126/sciadv.1700279

Uzdavinys, Povilas; Coinçon, Mathieu; Nji, Emmanuel; Ndi, Mama; Winkelmann, Iven; von Ballmoos, Christoph; Drew, David (2017). Dissecting the proton transport pathway in electrogenic Na + /H + antiporters. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 114(7), E1101-E1110. National Academy of Sciences NAS 10.1073/pnas.1614521114

von Ballmoos, Christoph; Smirnova, Irina; Poiana, Federica; Gonska, Nathalie; Chang, Hsin-Yang; Gennis, Robert B.; Brzezinski, Peter; Ädelroth, Pia (2017). Dynamics of the K B Proton Pathway in Cytochrome ba 3 from Thermus thermophilus. Israel journal of chemistry, 57(5), pp. 424-436. Wiley-VCH 10.1002/ijch.201600136

Smirnova, Irina A.; Sjöstrand, Dan; Li, Fei; Björck, Markus; Schäfer, Jacob; Östbye, Henrik; Högbom, Martin; von Ballmoos, Christoph; Lander, Gabriel C.; Ädelroth, Pia; Brzezinski, Peter (2016). Isolation of yeast complex IV in native lipid nanodiscs. Biochimica et biophysica acta - biomembranes, 1858(12), pp. 2984-2992. Elsevier 10.1016/j.bbamem.2016.09.004

Graf, Simone Sandra; Fedotovskaya, Olga; Kao, Wei-Chun; Hunte, Carola; Ädelroth, Pia; Bott, Michael; von Ballmoos, Christoph; Brzezinski, Peter (2016). Rapid Electron Transfer within the III-IV Supercomplex in Corynebacterium glutamicum. Scientific Reports, 6(1) Nature Publishing Group 10.1038/srep34098

Rydström Lundin, Camilla; von Ballmoos, Christoph; Ott, Martin; Ädelroth, Pia; Brzezinski, Peter (2016). Regulatory role of the respiratory supercomplex factors in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 113(31), E4476-E4485. National Academy of Sciences NAS 10.1073/pnas.1601196113

Biner, Olivier Felix; Schick, Thomas; Müller, Yannic; von Ballmoos, Christoph (2016). Delivery of membrane proteins into small and giant unilamellar vesicles by charge-mediated fusion. FEBS letters, 590(14), pp. 2051-2062. Wiley 10.1002/1873-3468.12233

Nilsson, Tobias; Lundin, Camilla Rydström; Nordlund, Gustav; Ädelroth, Pia; von Ballmoos, Christoph; Brzezinski, Peter (2016). Lipid-mediated Protein-protein Interactions Modulate Respiration-driven ATP Synthesis. Scientific Reports, 6(24113), p. 24113. Nature Publishing Group 10.1038/srep24113

von Ballmoos, Christoph; Biner, Olivier Felix; Nilsson, Tobias; Brzezinski, Peter (2016). Mimicking respiratory phosphorylation using purified enzymes. Biochimica et biophysica acta - bioenergetics, 1857(4), pp. 321-331. Elsevier 10.1016/j.bbabio.2015.12.007

von Ballmoos, Christoph; Gonska, Nathalie; Lachmann, Peter; Gennis, Robert B.; Ädelroth, Pia; Brzezinski, Peter (2015). Mutation of a single residue in the ba 3 oxidase specifically impairs protonation of the pump site. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 112(11), pp. 3397-3402. National Academy of Sciences NAS 10.1073/pnas.1422434112

Lindholm, Ljubica; Ariöz, Candan; Jawurek, Michael; Liebau, Jobst; Mäler, Lena; Wieslander, Åke; von Ballmoos, Christoph; Barth, Andreas (2015). Effect of lipid bilayer properties on the photocycle of green proteorhodopsin. Biochimica et biophysica acta - bioenergetics, 1847(8), pp. 698-708. Elsevier 10.1016/j.bbabio.2015.04.011

Biner, Olivier Felix; Trachsel, Christian; Moser, Aline Isabelle; Kopp, Lukas; Langenegger, Nicolas; Kämpfer, Urs; von Ballmoos, Christoph; Nentwig, Wolfgang; Schürch, Stefan; Schaller, Johann; Kuhn-Nentwig, Lucia Gerda (2015). Isolation, N-glycosylations and Function of a Hyaluronidase-Like Enzyme from the Venom of the Spider Cupiennius salei. PLoS ONE, 10(12), e0143963. Public Library of Science 10.1371/journal.pone.0143963

Lee, C.; Yashiro, S.; Dotson, D. L.; Uzdavinys, P.; Iwata, S.; Sansom, M. S. P.; von Ballmoos, Christoph; Beckstein, O.; Drew, D.; Cameron, A. D. (2014). Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights. Journal of general physiology, 144(6), pp. 529-544. Rockefeller University Press 10.1085/jgp.201411219

Nordlund, Gustav; Brzezinski, Peter; von Ballmoos, Christoph (2014). SNARE-fusion mediated insertion of membrane proteins into native and artificial membranes. Nature communications, 5(1) Nature Publishing Group 10.1038/ncomms5303

Lee, Chiara; Kang, Hae Joo; von Ballmoos, Christoph; Newstead, Simon; Uzdavinys, Povilas; Dotson, David L.; Iwata, So; Beckstein, Oliver; Cameron, Alexander D.; Drew, David (2013). A two-domain elevator mechanism for sodium/proton antiport. Nature, 501(7468), pp. 573-577. Macmillan Journals Ltd. 10.1038/nature12484

Oliynyk, Vitaliy; Mille, Christian; Ng, Jovice B. S.; von Ballmoos, Christoph; Corkery, Robert W.; Bergström, Lennart (2013). Selective and ATP-driven transport of ions across supported membranes into nanoporous carriers using gramicidin A and ATP synthase. Physical Chemistry Chemical Physics, 15(8), pp. 2733-2740. Royal Society of Chemistry 10.1039/c2cp43166a

Newspaper or Magazine Article

Ho, Manh Tin; Berger, Stephan; Müller, Philipp; Simonin, Céline; Reymond, Jean-Louis; von Ballmoos, Christoph; Fuster, Daniel G. (21 December 2022). Physiological and Molecular Function of the Sodium/Hydrogen Exchanger NHA2 (SLC9B2). CHIMIA, 76(12), pp. 1019-1024. Swiss Chemical Society 10.2533/chimia.2022.1019

Book Section

Sjöstrand, Dan; Högbom, Martin; von Ballmoos, Christoph (2020). Membrane‐Bound Superoxide Oxidase. In: Encyclopedia of Inorganic and Bioinorganic Chemistry (pp. 1-10). Wiley 10.1002/9781119951438.eibc2738

Conference or Workshop Item

Biner, Olivier Felix; Schick, Thomas; von Ballmoos, Christoph (27 August 2018). Delivery of respiratory chain enzymes into membrane mimicking systems by charge-mediated fusion (Unpublished). In: International Conference on Molecular Systems Engineering (ICMSE). Basel. 27-29.08.17.

Amati, Andrea Marco; Schär, Sandra; von Ballmoos, Christoph (27 August 2017). Towards unidirectional reconstitution of membrane proteins into liposomes. (Unpublished). In: 1st International Conference of Molecular Systems Engineering. University of Basel, Switzerland. 27.-29.08.2017.

Graf, Simone; von Ballmoos, Christoph; Brzezinksi, Peter (4 June 2017). Proton pumping bo3 oxidase from Vitreoscilla (Unpublished). In: Gordon Research Conference Bioenergetics. Proctor Academy Andover NH. 04.06.2017-09.06.2017.

Biner, Olivier Felix; von Ballmoos, Christoph (4 June 2017). Delivery of respiratory chain enzymes into membrane mimicking systems by charge-mediated fusion (Unpublished). In: Gordon research conference - Bioenergetics. Andover, New Hampshire, USA. 04.-09.06.2017.

Biner, Olivier Felix; von Ballmoos, Christoph (1 October 2016). Towards synthetic respiration – methods for the co-reconstitution of respiratory chain enzymes (Unpublished). In: Architecture and Functional Dynamics of the Cellular Power Plant. 30.09-01.10.2016. Sigtuna, Sweden.

Graf, Simone Sandra; von Ballmoos, Christoph; Brzezinski, Peter (30 September 2016). Rapid Electron Transfer within the III-IV Supercomplex in Corynebacterium glutamicum. And the bo3 quinol oxidase of vitreoscilla. (Unpublished). In: KAW Conference Sigtuna Stockholm. Stockholm. 30.09.2016.

Meyrat, Axel Alexandre; von Ballmoos, Christoph (30 September 2016). The Use of a Modified ATP to study the Effect of ATP on ATP Synthesis (Unpublished). In: KAW Project Cellular Power Plant Retreat.

Amati, Andrea Marco; von Ballmoos, Christoph (25 September 2016). Towards Unidirectional Reconstitution Of Membrane Proteins Into Liposomes (Unpublished). In: Annual Meeting of the German Biophysical Society 2016. Erlangen, Deutschland. 25.-28. September 2016.

Biner, Olivier Felix; Schick, Thomas; von Ballmoos, Christoph (11 September 2016). Fusion of oppositely charged proteoliposomes as a method for membrane protein co-reconstitution (Unpublished). In: Liposomes, Exosomes, and Virosomes: From Modeling Complex Membrane Processes to Medical Diagnos-tics and Drug Delivery. Ascona, Switzerland. 11.-16.09.2016.

Biner, Olivier Felix; Schick, Thomas; von Ballmoos, Christoph (2 July 2016). Towards synthetic respiration – methods for the co-reconstitution of respiratory chain enzymes (Unpublished). In: During oxidative phosphorylation in bacteria and mitochondria, membrane embedded complexes I to V functionally interact to form ATP from cellular reducing equivalents. Normally, these enzymes are investigated individually and therefore, their functional i. Riva del Garda. 02.-07.07.2016.

von Ballmoos, Christoph (2015). Membrane fusion as a tool for co-reconstitution of membrane proteins into liposomes (Unpublished). In: CEF‐Symposium: Structures, Mechanism and Dynamics of Membrane Complexes. Bad Homburg, Germany. 24.-25.09.015.

Nordlund, Gustav; Brzezinski, Peter; von Ballmoos, Christoph (July 2014). SNARE-fusion mediated inserton of membrane proteins into native and artificial membranes (Unpublished). In: European Bioenergetics Conference. Lisbon, Portugal. 12.-17.07.2014.

Working Paper

Abou-Hamdan, Abbas; Mahler, Roman; Grossenbacher, Philipp; Biner, Olivier; Sjöstrand, Dan; Lochner, Martin; Högbom, Martin; von Ballmoos, Christoph (23 December 2021). Functional design of bacterial superoxide:quinone oxidoreductase (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2021.12.23.473985

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